{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:29:04Z","timestamp":1784903344704,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025ZD0545900"],"award-info":[{"award-number":["2025ZD0545900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025ZD0545901"],"award-info":[{"award-number":["2025ZD0545901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025ZD0545902"],"award-info":[{"award-number":["2025ZD0545902"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501962"],"award-info":[{"award-number":["82501962"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>We aimed to assess the safety of continuous uterus\u2010preserving treatment among patients with endometrial cancer (EC) and atypical endometrial hyperplasia (AEH) who gave birth after progestin\u2010based fertility\u2010sparing treatment\u00a0(FST).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>From January 2005 to June 2020, we conducted a retrospective cohort study at Peking University People's Hospital, China, comprising 212 patients with EC or AEH who underwent FST. The participants were categorized into two groups based on the reproductive outcome of live birth. Risk factors were analyzed for disease recurrence in the entire cohort, and additional analysis was conducted on postpartum recurrence specifically in the live birth group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 212 eligible patients, 73 had a live birth, and 139 did not have a live birth after FST. Multivariable Cox analysis showed that live birth significantly reduced the risk of disease recurrence (HR 0.326,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011), while insulin resistance was identified as an adverse factor (HR 3.216,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014). Except for two patients who underwent hysterectomy, among 71 patients undergoing uterus preservation after live birth, five (7%) patients experienced disease relapse (two EC and three AEH) after a median follow\u2010up of 26 (11, 47.5) months. Four out of these five patients with recurrence achieved a complete response after a second round of FST. Eight other patients (11.3%) experienced hyperplasia without atypical (EH) after live birth. Potential risk factors for postpartum recurrence of EC\/AEH included irregular menstruation (80% vs. 39%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.153), abnormal ultrasonographic findings (60% vs. 18.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.065), and increased endometrial thickness (0.82\u2009cm vs.\u00a00.55\u2009cm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017). While postpartum maintenance therapy was identified as a protective factor against recurrence (0% vs. 62.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012). Notably, patients with postpartum recurrence may achieve a complete response with repeat FST.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although live birth was associated with improved recurrence\u2010free survival in patients with EC or AEH receiving FST, postpartum recurrence remains a concern. Irregular menstruation and abnormal ultrasound findings were identified as key risk factors for recurrence, while maintenance therapy exhibited a protective effect. These findings highlight the need for vigilant postpartum monitoring in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70139","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T08:36:12Z","timestamp":1771317372000},"page":"621-628","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Is it safe to preserve uterus after live birth following progestin\u2010based fertility\u2010sparing treatment for endometrial cancer or atypical hyperplasia: A long\u2010term retrospective cohort study"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-4802","authenticated-orcid":false,"given":"Yiqin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Bo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerui","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Research Institute Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5873-2146","authenticated-orcid":false,"given":"Qun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beijing Chao\u2010Yang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's Hospital  Beijing 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