{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T11:23:53Z","timestamp":1775301833734,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T00:00:00Z","timestamp":1771718400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNFSA170030576"],"award-info":[{"award-number":["NNFSA170030576"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF23SA0087869"],"award-info":[{"award-number":["NNF23SA0087869"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      In women with a regular cycle, reliable last menstrual period (LMP), and accurate crown\u2013rump length (CRL) estimation, discrepancies in estimated date of delivery (EDD) may indicate impaired fetal growth and increased risk of morbidity. This study examines whether discrepancies between EDD based on LMP (EDD\n                      <jats:sub>LMP<\/jats:sub>\n                      ) and CRL (EDD\n                      <jats:sub>CRL<\/jats:sub>\n                      ) are associated with chromosomal aberrations, adverse pregnancy outcomes, and obstetric complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      A Danish nationwide register\u2010based cohort study including all singleton pregnancies with both CRL and LMP registered between 2008 and 2018. Exclusion criteria were uncertain LMP, irregular menstrual cycle, EDD discrepancies &gt;\u00b128\u2009days, assisted reproductive technology, and missing outcome data. The cohort was stratified into seven groups according to EDD\n                      <jats:sub>LMP<\/jats:sub>\n                      \u2010EDD\n                      <jats:sub>CRL<\/jats:sub>\n                      discrepancy. Negative discrepancies indicated smaller\u2010than\u2010expected CRL, positive discrepancies indicated larger\u2010than\u2010expected CRL, and \u00b13\u2009days served as reference. Outcomes included chromosomal aberrations, major structural malformations, pregnancy loss, termination of pregnancy, fetal growth restriction, preterm birth, and obstetric complications (preeclampsia, preterm pre\u2010labour rupture of membranes, placenta previa, and placental abruption). Prevalence with 95% confidence intervals and adjusted odds ratios (aOR) were calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 262\u2009329 pregnancies were included; 16% had smaller and 21% had larger CRL than expected from LMP. Negative discrepancies were significantly associated with increased risk of chromosomal aberrations, adverse pregnancy outcomes, and obstetric complications. In the \u22128 to \u221214\u2009days group, 1.28% had a chromosomal abnormality (aOR 2.77 [95% CI 2.30\u20133.31]), and risk remained elevated among pregnancies at low combined first\u2010trimester screening risk (aOR 1.95 [1.55\u20132.43]). For triploidy and trisomy 18, 91% and 59% of cases, respectively, had discrepancies of &lt;\u22123\u2009days. In the \u22128 to \u221214\u2009days group, adverse pregnancy outcome occurred in 11.0% (aOR 1.49 [1.40\u20131.59]), and 6.5% had obstetric complications, mainly preeclampsia (aOR 1.19 [1.10\u20131.29]). Conversely, positive discrepancies were associated with reduced risk of chromosomal abnormalities (aOR 0.67 [0.44\u20130.96]) and adverse pregnancy outcomes (aOR 0.77 [0.69\u20130.86]) in the +8 to +14\u2009days group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A smaller than expected CRL was strongly associated with chromosomal aberrations, adverse pregnancy outcomes, and obstetric complications. Incorporating EDD discrepancies into risk algorithms for genetic disease, growth restriction, and preeclampsia may improve prediction and warrants further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70140","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T07:42:44Z","timestamp":1771832564000},"page":"693-702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discrepancy in menstrual and ultrasound\u2010based gestational age is associated with chromosomal aberrations and adverse pregnancy outcomes\u2014Results from a nationwide cohort study"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2059-7710","authenticated-orcid":false,"given":"Simone","family":"Hansen","sequence":"first","affiliation":[{"name":"Center of Fetal Medicine, Department of Gynecology, Fertility, and Pregnancy Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8517-4082","authenticated-orcid":false,"given":"Olav Bj\u00f8rn","family":"Petersen","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine, Department of Gynecology, Fertility, and Pregnancy Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1125-0393","authenticated-orcid":false,"given":"Ida","family":"Vogel","sequence":"additional","affiliation":[{"name":"Center for Fetal Diagnostics Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Obstetrics and Gynaecology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina Gros","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nordsjaellands Hospital  Hilleroed Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6726-1991","authenticated-orcid":false,"given":"Lars Henning","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Obstetrics and Gynaecology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-4738","authenticated-orcid":false,"given":"Steffen Ernesto","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine, Department of Gynecology, Fertility, and Pregnancy Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Faculty of Health and Medical Sciences, Institute of Cellular and Molecular Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5598-5773","authenticated-orcid":false,"given":"Karin","family":"Sundberg","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine, Department of Gynecology, Fertility, and Pregnancy Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6546-5544","authenticated-orcid":false,"given":"Emilie","family":"Thorup","sequence":"additional","affiliation":[{"name":"Center of Fetal Medicine, Department of Gynecology, Fertility, and Pregnancy Copenhagen University Hospital, Rigshospitalet  Copenhagen 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