{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T11:23:27Z","timestamp":1775301807077,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010711","name":"Sy\u00f6p\u00e4s\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The potential effect of induced abortion and miscarriage on the risk of breast cancer has remained debated and has been a persistent source of misinformation. Many previous studies have been small and based on self\u2010reported data. We assessed the associations of induced abortion and miscarriage with the risk of pre\u2010 and postmenopausal breast cancer using high\u2010quality Finnish registry data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This is a case\u2013control study based on population\u2010based registry data. It includes 31\u2009687 women with breast cancer diagnosed between 1972 and 2021, and their 158\u2009433 female population controls matched by birth year and parity. Data on induced abortions, miscarriages, deliveries, use of postmenopausal hormone therapy, socioeconomic status (SES), and occupation were collected from the Finnish national registries. Multivariate conditional logistic regression analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The odds ratio (OR) of breast cancer among women with a history of induced abortion as compared with women with no history of induced abortion was 1.01 (95% confidence interval [CI] 0.92\u20131.10) in premenopausal (age &lt;50 years) and 0.96 (95% CI 0.87\u20131.07)\u00a0in postmenopausal (\u226550 years) women. The corresponding ORs for miscarriage were 1.02 (95% CI 0.89\u20131.16) and 0.93 (95% CI 0.80\u20131.09). The OR did not vary significantly by the number of induced abortions or miscarriages, nor by the age at the time of first induced abortion or miscarriage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A history of induced abortion and miscarriage, regardless of their number or age of the woman, is not associated with an increased risk of subsequent pre\u2010 or postmenopausal breast cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70154","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T08:01:46Z","timestamp":1770796906000},"page":"596-603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Induced abortion, miscarriage, and the risk of breast cancer\u2014A registry\u2010based study from Finland"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3017-9430","authenticated-orcid":false,"given":"Sushmita","family":"Katuwal","sequence":"first","affiliation":[{"name":"Unit of Health Sciences, Faculty of Social Medicine Tampere University  Tampere Finland"},{"name":"University of Helsinki Department of Public Health, Faculty of Medicine  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4466-619X","authenticated-orcid":false,"given":"Jaana","family":"M\u00e4nnist\u00f6","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center Oulu University Hospital of Oulu and University of Oulu  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0927-0472","authenticated-orcid":false,"given":"Maarit","family":"Niinim\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center Oulu University Hospital of Oulu and University of Oulu  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9536-6440","authenticated-orcid":false,"given":"Eero","family":"Pukkala","sequence":"additional","affiliation":[{"name":"Unit of Health Sciences, Faculty of Social Medicine Tampere University  Tampere Finland"},{"name":"Finnish Cancer Registry Institute for Statistical and Epidemiological Cancer Research  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8671-130X","authenticated-orcid":false,"given":"Oskari","family":"Heikinheimo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2022.08.010"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03502-3"},{"key":"e_1_2_13_4_1","unstructured":"Lar\u00f8nningenS ArvidssonG BrayF et\u00a0al.NORDCAN: cancer incidence mortality prevalence and survival in the Nordic countries version 9.4 (29.08.2024). 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