{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:56:47Z","timestamp":1780354607178,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Atypical placental site nodule (APSN) is a rare diagnosis, representing remnants of a previous pregnancy and extravillous trophoblast tissue. These lesions are potential precursor lesions to rare forms of Gestational trophoblastic neoplasia (GTN). Recent data suggest up to a 15% risk of malignancy occurring either concurrently or manifesting within a few months of diagnosis. These patients are often young with future fertility considerations. Prognosis, treatment, and clinical follow\u2010up of APSN cases currently remain a matter of debate. This study aimed to address and explore some of these issues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Retrospective case series analysis was performed between 1st January 2000 and 31st December 2023 at the Sheffield Trophoblastic Disease Centre, Sheffield, UK. Patients on conservative management were asked at routine follow\u2010up telephone consultations if they would consider a completion hysterectomy in light of the risk of progression to GTN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010two cases of APSN were registered, of which 10 (45%) received surgical management. Two (20%) cases were incidentally diagnosed following total abdominal hysterectomy (TAH) for other indications and eight (80%) had a TAH within twelve months of their initial diagnosis as part of primary management. None had histological evidence of GTN.<\/jats:p>\n                    <jats:p>Of the twelve (55%) patients initially opting primarily for conservative management, three (25%) decided to have a TAH performed based on the current evidence for risk of malignant transformation, eight (67%) indicated they would have a TAH based on advice from the center, and one (8%) was uncertain. No patients were diagnosed with GTN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this study, we found no evidence of malignant transformation in our patients, which conflicts with other published data conferring an 11%\u201314% risk of malignant transformation. An international consensus opinion needs to be reached within the Gestational trophoblastic community regarding the optimal advice, management, and follow\u2010up regimens for patients diagnosed with APSN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70160","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:42:45Z","timestamp":1772962965000},"page":"687-692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Atypical placental site nodules: A retrospective case series"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8748-4583","authenticated-orcid":false,"given":"Victoria Louise","family":"Parker","sequence":"first","affiliation":[{"name":"Department of Gynaecological Oncology Sheffield Teaching Hospitals NHS Foundation Trust  Sheffield UK"},{"name":"School of Medicine and Population Health The University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0401-6966","authenticated-orcid":false,"given":"Kamaljit","family":"Singh","sequence":"additional","affiliation":[{"name":"Sheffield Trophoblastic Disease Centre, Sheffield Teaching Hospitals NHS Foundation Trust  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-9437","authenticated-orcid":false,"given":"Katie","family":"McDonald","sequence":"additional","affiliation":[{"name":"South Yorkshire and Bassetlaw Pathology, Sheffield Teaching Hospitals NHS Foundation Trust  Sheffield UK"},{"name":"Sheffield Trophoblastic Disease Centre  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Jabbar","sequence":"additional","affiliation":[{"name":"Sheffield Trophoblastic Disease Centre, Sheffield Teaching Hospitals NHS Foundation Trust  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew Christopher","family":"Winter","sequence":"additional","affiliation":[{"name":"School of Medicine and Population Health The University of Sheffield  Sheffield UK"},{"name":"Sheffield Trophoblastic Disease Centre  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Elizabeth","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology Sheffield Teaching Hospitals NHS Foundation Trust  Sheffield UK"},{"name":"Sheffield Trophoblastic Disease Centre, Sheffield Teaching Hospitals NHS Foundation Trust  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199407000-00001"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199011000-00002"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90088-4"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1996.tb01424.x"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(00)80064-3"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-008-0075-y"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60618-8"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.12.033"},{"key":"e_1_2_13_10_1","unstructured":"TidyJA SecklM HancockBW.Gestational Trophoblastic Disease (Green\u2010top Guideline No. 38).2020."},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-200101000-00004"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90095-3"},{"key":"e_1_2_13_13_1","volume-title":"Who\u2010Classification\u2010Of\u2010Tumours\/Female\u2010Genital\u2010Tumours","year":"2020"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2022.100046"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-8-85"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.03145.x"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000128"},{"key":"e_1_2_13_18_1","unstructured":"SarwarN AguiarX MaherG et\u00a0al.Atypical placental site nodule (APSN) and association with malignant Gestational trophoblastic disease; A clinicopathologic study. 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