{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:10:57Z","timestamp":1777633857323,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Currently, the Test of Cure after conization consists of two elements, namely human papillomavirus (HPV) testing and cytology. Given the high sensitivity of HPV testing and its modest resource requirements, we will explore its potential as a stand\u2010alone test for identifying persistent\/recurrent cervical intraepithelial neoplasia (CIN) during follow\u2010up after conization, including women at increased risk, such as those with involved resection margins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This retrospective study examined 473 women who underwent conization in Funen, Denmark, between January 1, 2020, and December 31, 2024. During the post\u2010conization follow\u2010up period, data were manually extracted from patients' medical records and PatoBank.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the follow\u2010up, cervical intraepithelial neoplasia grade 1 or worse (CIN1+) persistent\/recurrence was experienced by 55 women (11.6%) (median age of 42\u2009years (range 22\u201387\u2009years)). Among those with involved margins, 30.3% (40\/132) experienced persistent\/recurrent CIN1+ compared to 3.6% (7\/193) with free margins; and 66.4% (314\/473) tested negative for high\u2010risk HPV after conization, and only four of them developed persistent\/recurrent CIN1+. HPV testing alone predicted the risk of CIN1+ persistence\/recurrence with 93% sensitivity and 98.7% negative predictive value (NPV). Combining negative HPV test results with free resection margins yielded a sensitivity and NPV of 100%. Co\u2010testing combined with free margins also provided a sensitivity and NPV of 100%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Using HPV testing as a stand\u2010alone test after conization demonstrates an NPV nearly equal to that of the Test of Cure. Adding free margins to HPV testing further enhanced sensitivity and NPV for detecting CIN1+ persistence or relapse during follow\u2010up. Our results indicate that HPV testing alone can be used as post\u2010conization follow\u2010up for women with negative margins.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70168","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T15:41:47Z","timestamp":1773070907000},"page":"960-968","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Accuracy of human papillomavirus testing in detecting persistent or recurrent disease at follow\u2010up after conization"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4157-3843","authenticated-orcid":false,"given":"Ghina","family":"Alaref","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences University of Southern Denmark  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense 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