{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:35:09Z","timestamp":1790199309633,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The prevalence of unexplained recurrent implantation failure (RIF) is reported as 2%\u201315% in the literature. The variation in prevalence reflects the heterogeneity in definition. Recent work has suggested unexplained RIF is unlikely to be endometrial or cycle synchronicity related but is, in fact, an embryological phenomenon. The most likely embryological phenomenon is aneuploidy. Preimplantation genetic testing for aneuploidy (PGT\u2010A) has proven to reduce miscarriage rates in almost all infertility patients, including those with recurrent pregnancy loss, suggesting aneuploidy plays an important role in unsuccessful in\u00a0vitro fertilization. No guidance for PGT\u2010A use in RIF exists. This review aimed to address this evidence gap.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>A systematic search of Medline, Embase, Web of Science, CINAHL, and Cochrane Database from inception until November 2024 was undertaken. Selection criteria included experimental and observational studies comparing euploid blastocyst transfer using PGT\u2010A to standard care. The population included those with RIF or undergoing a minimum of three transfers. The primary outcome was cumulative live birth rate (CLBR). The primary aim of this review is to evaluate the impact of PGT\u2010A on live birth rate (LBR) following a diagnosis of RIF. The secondary aim was to estimate the true prevalence of RIF, using a definition of three failed cycles. A random effects meta\u2010analysis was conducted reporting pooled odds ratios between groups using IBM SPSS v29.0.2.0 (20). The review was prospectively registered on PROSPERO:CRD42024580037.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 13 studies were included with low\u2010to\u2010moderate risk of bias. Eleven studies addressed PGT\u2010A after an RIF diagnosis while two studies addressed RIF prevalence after successive PGT\u2010A cycles. Four studies reported a statistically significant increase in CLBR with OR 4.23 [95% CI: 2.14, 8.38]. Similar results were seen in studies reporting a single embryo transfer using PGT\u2010A following an RIF diagnosis, OR 2.79 [95% CI: 1.90, 4.10].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PGT\u2010A results in a statistically significant increase in both LBR per embryo transfer and CLBR per cycle. This finding supports the hypothesis that RIF may be an embryological phenomenon. Further research is required before routine recommendation of PGT\u2010A for the management of RIF can be inferred.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70175","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:32:47Z","timestamp":1772969567000},"page":"575-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Does preimplantation genetic testing for aneuploidy improve live birth rate in women diagnosed with recurrent implantation failure: A systematic review and meta\u2010analysis?"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7656-6201","authenticated-orcid":false,"given":"Amy","family":"Newnham","sequence":"first","affiliation":[{"name":"Division of Biomedical Science, Clinical Research Laboratories, Warwick Medical School University of Warwick  Coventry UK"},{"name":"University Hospitals Coventry and Warwickshire  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4735-2452","authenticated-orcid":false,"given":"Charlotte","family":"Leeson","sequence":"additional","affiliation":[{"name":"Department of Applied Health Sciences, School of Health Sciences, College of Medicine and Health University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Trunkwala","sequence":"additional","affiliation":[{"name":"University Hospitals Coventry and Warwickshire  Coventry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Odendaal","sequence":"additional","affiliation":[{"name":"Division of Biomedical Science, Clinical Research Laboratories, Warwick Medical School University of Warwick  Coventry UK"},{"name":"University Hospitals Coventry and Warwickshire  Coventry 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