{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:11:06Z","timestamp":1777633866579,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Infertility is a common reproductive health issue, associated with increased risks of pregnancy complications. However, shared underlying risk factors such as age, BMI, PCOS, endometriosis, and lifestyle may partly explain these associations. In a population\u2010based cohort of women, this study aimed to determine whether a history of fertility problems is independently associated with adverse pregnancy and birth outcomes, including gestational diabetes, hypertensive disorders of pregnancy, low birthweight, and preterm birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      This was a secondary analysis of data from the 1973 to 1978 cohort of the Australian Longitudinal Study on Women's Health, that included surveys from 2003 to 2018 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099854). We examined associations between self\u2010reported fertility problems and four adverse outcomes: gestational diabetes, hypertensive disorders of pregnancy, low birthweight, and preterm birth. Generalized estimating equations with an exchangeable correlation structure were used, with sequential adjustment for socio\u2010demographic, health, and lifestyle\u2010related characteristics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 5653 women who reported a live birth, 897 (15.9%) reported a history of fertility problems, of whom 71.6% had sought help. After adjusting for socio\u2010demographic factors alone, there was a statistically significant increased risk of adverse pregnancy outcomes for women with a history of fertility problems compared to those without. However, after further adjustment for health characteristics and pregnancy\u2010related variables, the associations were no longer statistically significant: gestational diabetes [Relative risk (RR): 0.98; 95% confidence interval (CI) (0.78 to 1.22)], hypertensive disorders of pregnancy [RR: 1.08; 95% CI (0.82 to 1.43)], preterm birth [RR: 1.01; 95% CI (0.81 to 1.26)], or low birthweight [RR: 1.04; 95% CI (0.80 to 1.34)].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this large cohort of women in Australian, initial associations between fertility problems and adverse pregnancy outcomes were attenuated after adjustment for key health and lifestyle factors. The absence of associations in fully adjusted models suggests that previously reported risks may reflect shared underlying maternal characteristics rather than infertility itself and highlights the importance of cautious interpretation of statistical significance in large observational studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70178","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T13:14:21Z","timestamp":1772975661000},"page":"859-867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between history of fertility problems and pregnancy and birth complications: A longitudinal population\u2010based cohort study"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2750-209X","authenticated-orcid":false,"given":"Cathryn A.","family":"Tully","sequence":"first","affiliation":[{"name":"Adelaide Medical School and the Robinson Research Institute Adelaide University  Adelaide South Australia Australia"},{"name":"Repromed  Dulwich South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7652-990X","authenticated-orcid":false,"given":"Danielle","family":"Schoenaker","sequence":"additional","affiliation":[{"name":"School of Human Development and Health, Faculty of Medicine University of Southampton  Southampton UK"},{"name":"MRC Lifecourse Epidemiology Centre University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leanne","family":"Pacella\u2010Ince","sequence":"additional","affiliation":[{"name":"Adelaide Medical School and the Robinson Research Institute Adelaide University  Adelaide South Australia Australia"},{"name":"Repromed  Dulwich South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5464-2197","authenticated-orcid":false,"given":"Allison M.","family":"Hodge","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne  Parkville Victoria Australia"},{"name":"Cancer Epidemiology Division Cancer Council Victoria  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1515-948X","authenticated-orcid":false,"given":"Jessica A.","family":"Grieger","sequence":"additional","affiliation":[{"name":"Adelaide Medical School and the Robinson Research Institute Adelaide University  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"WHO. World Health Organization.Infertility.2024.https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/infertility"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2014.09.005"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2014.5000"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S488351"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab224"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000287293.25465.e1"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2018.00211"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03426-3"},{"issue":"10","key":"e_1_2_14_10_1","first-page":"945","article-title":"Cigarette smoking and fertility in women and men","volume":"34","author":"Sepaniak S","year":"2006","journal-title":"Gynecol Obstet Fertil"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf194"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmaa011"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg444"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000290330.80256.97"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem311"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des347"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.02.027"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyi098"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det256"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1998.tb140192.x"},{"issue":"8","key":"e_1_2_14_21_1","first-page":"528","article-title":"Gestational diabetes mellitus\u2010\u2010negotiating the confusion","volume":"42","author":"Nankervis A","year":"2013","journal-title":"Aust Fam Physician"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2009.01003.x"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-6405.2008.00305.x"},{"issue":"1","key":"e_1_2_14_24_1","first-page":"19","article-title":"Development of the Melbourne FFQ: a food frequency questionnaire for use in an Australian prospective study involving an ethnically diverse cohort","volume":"3","author":"Ireland P","year":"1994","journal-title":"Asia Pac J Clin Nutr"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2008.10719686"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2010.01.002"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-015-0597-x"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(23)01971-4"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.12.033"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2006.08.004"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00489.x"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000114989.84822.51"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.02.043"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt110"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbms.2021.09.002"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv044"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1582397"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70178","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.70178","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:57:22Z","timestamp":1777438642000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.70178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/aogs.70178"],"URL":"https:\/\/doi.org\/10.1111\/aogs.70178","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"assertion":[{"value":"2025-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}