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The present study aimed to assess, in a population\u2010based birth cohort, whether women with PCOS are more likely to experience late peri\u2212\/postmenopause or to have menopausal symptoms in their mid\u201040s than women without the syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      The present study is a long\u2010term, population\u2010based prospective cohort study from the Northern Finland Birth Cohort 1966 (NFBC1966). The PCOS group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009380) was identified based on the Rotterdam criteria (oligomenorrhea, hyperandrogenism, or polycystic ovarian morphology according to anti\u2010M\u00fcllerian hormone levels). Women who did not meet the Rotterdam criteria for PCOS were considered as controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091469). Late peri\u2212\/postmenopause was defined as at least 60\u2009days of amenorrhea accompanied by elevated follicle\u2010stimulating hormone levels (&gt;25\u2009IU\/L) or the use of menopausal hormone therapy. In women who had undergone hysterectomy or were using progestins, menopausal status was defined as elevated follicle\u2010stimulating hormone levels (&gt;25\u2009IU\/L). Menopausal symptoms were self\u2010reported via questionnaire during a follow\u2010up visit at age 46.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Women with PCOS had a significantly lower likelihood of being late peri\u2212\/postmenopausal in their mid\u201040s compared with controls (PCOS: 3.1% vs. Controls: 18.4%; adjusted odds ratio 0.15, 95% confidence interval 0.07\u20130.32). To support this result, women with PCOS more often reported having regular menstrual cycles and had a lower risk of menopausal symptoms at age 46, even after adjusting for body mass index, education, and smoking status (adjusted odds ratio 0.68, 95% confidence interval 0.51\u20130.92). Hot flashes and sleep disturbances were less frequent among women with PCOS, but there were no differences in other menopause\u2010related symptoms, such as vaginal dryness, affective symptoms, memory disturbances, or sexual dysfunction between the study groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>From the nonselective population data, it was shown that late peri\u2212\/postmenopausal status and symptoms were less frequent in women with PCOS at age 46, supporting the idea of prolonged ovarian function in affected women. This should be considered in patient counseling and future studies of fertility, contraception, and menopausal hormone therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70198","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T12:14:49Z","timestamp":1775650489000},"page":"836-846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Women with\n                    <scp>PCOS<\/scp>\n                    have a later menopausal transition and a lower prevalence of menopausal symptoms at age 46: A population\u2010based birth cohort study"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8258-4544","authenticated-orcid":false,"given":"Johanna","family":"Lavi","sequence":"first","affiliation":[{"name":"Research Unit of Clinical Medicine, Department of Obstetrics and Gynecology, Medical Research Center Oulu University Hospital, 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