{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:12:01Z","timestamp":1779354721567,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pregnancy\u2010associated cancer is a rare but clinically significant event. Decisions regarding subsequent pregnancies after such a diagnosis are complex and influenced by medical, psychological, and social factors. This study aimed to investigate the probability of having a subsequent pregnancy following a diagnosis of a pregnancy\u2010associated cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We conducted a record\u2010linkage cohort study using the regional health databases of Lombardy, including the hospital discharge records and the certificate of delivery assistance. Pregnancies were deliveries and abortions occurring between 1 January 2007 and 31 December 2017. Pregnancy\u2010associated cancer was defined as any malignant neoplasm first diagnosed during pregnancy or within 1\u2009year after the end of pregnancy, identified through hospital admissions carrying a new cancer diagnosis. To ascertain subsequent pregnancies after a diagnosis of pregnancy\u2010associated cancer, we tracked deliveries and abortions through 31 December 2023. We estimated the incidence of pregnancy\u2010associated cancer per 1000 pregnancies with the corresponding 95% confidence intervals (CIs) and calculated the cumulative probability of a post\u2010diagnosis pregnancy using the cumulative incidence function that accounts for the competing risk of death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 832 incident pregnancy\u2010associated cancers were recorded among deliveries and 325 among abortions, corresponding to incidence rates of 1.12 per 1000 deliveries (95% CI, 1.04\u20131.19) and 1.27 per 1000 abortions (95% CI, 1.13\u20131.41). Breast cancer was the most frequent diagnosis in both groups (31% among deliveries, 40% among abortions), followed by thyroid cancer; the third most common site was lymphoma among deliveries and cervical cancer among abortions. During follow\u2010up, 77 women had a subsequent pregnancy (59 deliveries, 18 abortions), yielding a cumulative probability of 7.3%. Stratified by age at diagnosis, women under 35 had a substantially higher probability of subsequent pregnancy compared to women aged 35 or older (14.0% vs. 3.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Furthermore, the cumulative probability of subsequent pregnancy was lower among women treated with antineoplastic therapy than among those who were not treated (4.3% vs. 10.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Subsequent pregnancies following a pregnancy\u2010associated cancer diagnosis were relatively uncommon, highlighting the need for integrated reproductive counseling within a multidisciplinary approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70202","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T05:37:59Z","timestamp":1775713079000},"page":"1096-1103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Subsequent pregnancies after a diagnosis of pregnancy\u2010associated cancer"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7894-4456","authenticated-orcid":false,"given":"Giovanna","family":"Esposito","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023\u20102027 University of Milan  Milan Italy"},{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fedro Alessandro","family":"Peccatori","sequence":"additional","affiliation":[{"name":"Department of Gynecology European Institute of Oncology, IEO, IRCCS  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Franchi","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods University of Milano\u2010Bicocca  Milan Italy"},{"name":"National Centre for Healthcare Research and Pharmacoepidemiology  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Trojano","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health Madonna Delle Grazie Hospital  Matera Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Corrao","sequence":"additional","affiliation":[{"name":"Emeritus Professor of Medical Statistic University of Milano\u2010Bicocca  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1441-897X","authenticated-orcid":false,"given":"Carlo","family":"La Vecchia","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023\u20102027 University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Parazzini","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023\u20102027 University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Cantarutti","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Statistics and Quantitative Methods University of Milano\u2010Bicocca  Milan Italy"},{"name":"National Centre for Healthcare Research and Pharmacoepidemiology  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