{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:11:06Z","timestamp":1777633866818,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We conducted two systematic reviews including only randomized controlled trials (RCTs) comparing magnesium sulfate vs placebo\/no treatment, as well as 2 g\/h vs 1 g\/h magnesium sulfate maintenance regimens for prevention of eclampsia. Medline, Cochrane Library, EMBASE, PubMed Central, Scopus,\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrial.gov\">ClinicalTrial.gov<\/jats:ext-link>\n                    were electronically searched from their inception to February 2025. In the five RCTs comparing magnesium sulfate vs placebo\/no treatment, a 2\u2010g maintenance dose was used in two RCTs including 176 pregnancies, while a 1 g maintenance dose was used in three RCTs including 5447 pregnancies. Eclampsia incidence was 0.57% with the 2 g\/h regimen and 0.76% with the 1 g\/h regimen (OR 1.33, 95% CI: 0.18\u20139.60), while maternal side effects were significantly higher in the 2 g\/h regimen (67% vs 22%, OR 7.05, 95% CI: 4.22\u201311.78). In the five RCTs (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009283) comparing 2 g\/h vs 1 g\/h maintenance regimens, no case of eclampsia was reported with either regimen, and maternal side effects were significantly higher in the 2 g\/h group (71% vs 42%, OR 1.69, 95% CI: 1.06\u20132.71). In conclusion, magnesium sulfate maintenance regimen of 1 g\/h seems as effective as the 2 g\/h regimen for the prevention of eclampsia, with decreased incidence of maternal side effects.\n                  <\/jats:p>","DOI":"10.1111\/aogs.70205","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T12:01:21Z","timestamp":1775649681000},"page":"771-777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["1 g\/h magnesium sulfate maintenance for eclampsia prevention is enough"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3689-8042","authenticated-orcid":false,"given":"Alessandro","family":"Petrecca","sequence":"first","affiliation":[{"name":"Department of Woman and Child Health and Public Health Sciences, Fondazione Policlinico A. Gemelli IRCSS Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetta","family":"Bina","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health and Urological Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1823-1096","authenticated-orcid":false,"given":"Tullio","family":"Ghi","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health and Public Health Sciences, Fondazione Policlinico A. Gemelli IRCSS Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Berghella","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology Sidney Kimmel Medical College of Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016349509008935"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(97)70558-1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1998.tb10090.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(02)08778-0"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0029-7844(02)03053-3"},{"issue":"4","key":"e_1_2_11_7_1","first-page":"395","article-title":"Magnesium sulfate maintenance infusion in women with preeclampsia: a randomized comparison between 2 gram per hour and 1 gram per hour","volume":"96","author":"Charoenvidhya D","year":"2013","journal-title":"J Med Assoc Thail"},{"key":"e_1_2_11_8_1","first-page":"S133","article-title":"Comparison of the level of magnesium during maintenance between 2 gram and 1 gram per hour infusion in overweight mothers with preeclampsia","volume":"99","author":"Kitiyodom S","year":"2016","journal-title":"J Med Assoc Thail"},{"issue":"2","key":"e_1_2_11_9_1","first-page":"QC01","article-title":"Comparison of magnesium sulphate protocols by weight\u2010adjusted versus two grams per hour for preventing convulsion in preeclampsia: a randomised controlled trial","volume":"13","author":"Tangmanowutthikul S","year":"2019","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016779"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004137"},{"key":"e_1_2_11_12_1","volume-title":"Hypertension in Pregnancy: Diagnosis and Management","year":"2019"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.09.037"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13753"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641959409072226"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.70205","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:57:23Z","timestamp":1777438643000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.70205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,8]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/aogs.70205"],"URL":"https:\/\/doi.org\/10.1111\/aogs.70205","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,8]]},"assertion":[{"value":"2025-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}