{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:41:12Z","timestamp":1791650472244,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cervical cancer represents a significant public health challenge worldwide. To improve screening accessibility and participation, we implemented vaginal human papilloma virus (HPV) self\u2010sampling as part of an organized cervical cancer prevention strategy. This study aimed to evaluate the implementation and outcomes of the self\u2010sampling program in a real\u2010world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Between September 1, 2021 and December 31, 2024, a total of 557\u2009976 vaginal self\u2010sampling kits were distributed. Follow\u2010up with cervical sampling continued through April 2025. Data were collected using the Laboratory Information Management System (LIMS) and the Melior Journal system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the distributed kits, 208\u2009386 were returned, yielding an adherence rate of 37% (208\u2009386\/557\u2009976). Among the valid samples, 19% (39\u2009697\/204\u2009763) tested positive for HPV. Follow\u2010up adherence among HPV\u2010positive women was 81% (32\u2009305\/39\u2009697), defined as attendance at follow\u2010up clinics by the end of the fourth subsequent calendar month. Cervical samples were HPV\u2010positive in 39% (12\u2009495\/32\u2009305) and HPV16 or HPV18\/45 were detected in 2157 cases (17%). Cytological analysis identified high\u2010grade cervical dysplasia in 759 women (6.1%, 759\/12\u2009505) and histopathology confirmed its presence in 980 cases (13%, 980\/7641). Cervical cancer was diagnosed in 32 cervical biopsies (0.4%, 32\/7647).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The vaginal self\u2010sampling program was effective in detecting HPV. Its capacity to identify HPV types and significant cytological abnormalities underscores its potential for facilitating early detection, enhancing screening coverage and timely clinical intervention, thereby reducing the incidence of cervical cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70206","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T11:37:10Z","timestamp":1775648230000},"page":"1043-1051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010world evaluation of a population\u2010based vaginal self\u2010sampling program for cervical cancer prevention in Region Sk\u00e5ne, Sweden"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4206-7337","authenticated-orcid":false,"given":"Caroline","family":"Hellsten","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Sk\u00e5ne University Hospital  Lund Sweden"},{"name":"Department of Clinical Science Lund Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6293-7286","authenticated-orcid":false,"given":"Ola","family":"Forslund","sequence":"additional","affiliation":[{"name":"Clinical Microbiology, Infection Prevention and Control, Office for Medical Services Region Sk\u00e5ne, and Translational Medicine Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christer","family":"Borgfeldt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Department of Biomedical and Clinical Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_14_2_1","volume-title":"WHO Guidelines for Screening and Treatment of Precancerous Lesions for Cervical Cancer Prevention","author":"World Health Organization","year":"2021"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2018-001351"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.236"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151978"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.15112"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn099"},{"key":"e_1_2_14_8_1","volume-title":"F\u00f6rebyggande av livmoderhalscancer i Sverige. Verksamhetsber\u00e4ttelse och \u00e5rsrapport 2025 med data till och med 2024. [Prevention of Cervical Cancer in Sweden. 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