{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:20:22Z","timestamp":1783459222901,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To identify predictive factors of the absence of high\u2010grade intraepithelial lesion on large loop excision of the transformation zone specimen of patients with a previous histological diagnosis of high\u2010grade intraepithelial lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter retrospective study in nine hospitals. All patients treated by large loop excision of the transformation zone following histological diagnosis of high\u2010grade intraepithelial lesion between 2015 and 2021 were included. All patients had initial diagnosis of high\u2010grade intraepithelial lesion performed on cervical biopsy and\/or endocervical curettage. Clinical, cytological, colposcopic, and high\u2010grade intraepithelial lesion data were extracted from medical files. The primary endpoint was the absence of high\u2010grade intraepithelial lesion on the specimen, defined either by the identification of a low\u2010grade intraepithelial lesion only or by the absence of any intraepithelial lesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 2037 patients were included. The absence of high\u2010grade intraepithelial lesion was identified in 191 (9.4%) patients. Three predictive factors of high\u2010grade intraepithelial lesion absence on large loop excision of the transformation zone specimen were identified: a small abnormal transformation zone defined by cervical involvement less than or equal to one quadrant (aOR: 2.01; 95%CI: 1.47\u20132.75;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), a colposcopic impression of normal cervix or minor changes (aOR: 1.73; 95%CI: 1.24\u20132.42;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and normal or low\u2010grade or ASC\u2010US cytology (aOR: 1.37; 95%CI: 1.00\u20131.87;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Predictive factors of high\u2010grade intraepithelial lesion absence on large loop excision of the transformation zone specimen of patients with a histological diagnosis of high\u2010grade intraepithelial lesion are a small abnormal transformation zone, a colposcopic impression of normal cervix or minor changes, and normal, low\u2010grade or ASC\u2010US cytology. Practitioners should take these three elements into account when considering large loop excision of the transformation zone treatment in women with a proven diagnosis of high\u2010grade intraepithelial lesion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70213","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:03:32Z","timestamp":1781845412000},"page":"1240-1246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive factors for the absence of high\u2010grade intraepithelial lesions in LLETZ specimens following a prior histological diagnosis"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9270-2415","authenticated-orcid":false,"given":"Sophia","family":"Assirlikian","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology Department H\u00f4pital Nord, APHM  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Mancini","sequence":"additional","affiliation":[{"name":"Aix Marseille University, INSERM, IRD, ISSPAM, SESSTIM, Sciences Economiques &amp; Sociales de la Sant\u00e9 &amp; Traitement de l'Information M\u00e9dicale  Marseille France"},{"name":"Department of Biostatistics and Technologies of Information (BIOSTIC) H\u00f4pital de la Timone  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles\u2010Andr\u00e9","family":"Philip","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department H\u00f4pital Femme M\u00e8re Enfant, HCL  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffroy","family":"Canlorbe","sequence":"additional","affiliation":[{"name":"Department of Surgery &amp; Gynaecological and Breast Oncology H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri","family":"Aza\u00efs","sequence":"additional","affiliation":[{"name":"Gynecological and Breast Oncology Surgery Department H\u00f4pital Europ\u00e9en Georges Pompidou, APHP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Fuss\u2010Blanco","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department Hospital de Hautepierre  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Lecointre","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department Hospital de Hautepierre  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine Le Bail","family":"Carval","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department H\u00f4pital Femme M\u00e8re Enfant, HCL  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave","family":"Nkounawa","sequence":"additional","affiliation":[{"name":"Gynaecologic Surgery Department Centre Hospitalier de Calais  Calais France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriniaina","family":"Ravelojaona","sequence":"additional","affiliation":[{"name":"Gynaecology and Obstetrics Department Centre Hospitalier d'Avignon  Avignon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Carcopino","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynaecology Department H\u00f4pital Nord, APHM  Marseille France"},{"name":"Aix\u2010Marseille University (AMU), UnivAvignon, CNRS, IRD, IMBEUMR7263  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc798"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910520513"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00245-2"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000604"},{"issue":"3","key":"e_1_2_13_6_1","first-page":"1763","article-title":"Natural history of established low grade cervical intraepithelial (CIN 1) lesions","volume":"28","author":"Bansal N","year":"2008","journal-title":"Anticancer Res"},{"key":"e_1_2_13_7_1","unstructured":"Management of Women with Abnormal Cervical Cytology\u2014Thesaurus\u2014Ref: RECOCCUTHES2016 [Internet]. 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