{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:08:28Z","timestamp":1792382908375,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Endometriosis patients often suffer from more severe pain in association with surgical procedures. The aim of this study was to investigate whether laparoscopically guided transversus abdominis plane block (LTAP) offers an opioid\u2010sparing effect compared to local wound infiltration (LWI) analgesia in laparoscopic surgery performed for suspected peritoneal endometriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      In this single\u2010center prospective, randomized, controlled, double\u2010blinded clinical study, 46 patients were randomized to receive either levobupivacaine inserted in the four quadrants of the abdomen at LTAP points and saline at trocar sites (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923) or saline at the LTAP points and levobupivacaine at trocar sites (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923). The study size was based on a power calculation. The primary outcome, opioid consumption 24\u2009h postoperatively, was measured using patient\u2010controlled analgesia pumps. Secondary outcomes included postoperative pain scores and other enhanced recovery after surgery (ERAS) measures, as well as patient outcome questionnaires at six months after surgery. Statistical analyses were performed on an intention\u2010to\u2010treat basis. The study was prospectively registered in\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link>\n                      , ID: NCT04735770, Jan 19, 2021;\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT04735770?term=LTAP&amp;rank=2\">https:\/\/clinicaltrials.gov\/study\/NCT04735770?term=LTAP&amp;rank=2<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was no significant difference in the mean opioid consumption (iv morphine equivalents) between the study groups: 31.8 \u00b1\u200925.5\u2009mg in the LTAP group and 27.5 \u00b1\u200919.3\u2009mg in the LWI group (mean difference 4.3\u2009mg, 95% CI \u22129.2 to 17.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.52). No significant differences were found in the postoperative pains scores, mean operation times, mean total blood loss, or mobilization between the study groups. 17 (73.9%) patients in each group received histological diagnosis of peritoneal endometriosis of the samples obtained during surgery. Times to discharge were 24.4 \u00b1\u20094.3 (LTAP) and 28.1 \u00b1\u200914.8\u2009h (LWI),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.25. No complications related to LTAP or LWI were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this study performed on women suffering from long\u2010term abdominal pain preoperatively, no significant differences were found between LTAP and LWI as regards to postoperative opioid consumption, postoperative pain, ERAS factors, or safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70220","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:50:37Z","timestamp":1777603837000},"page":"1032-1042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Laparoscopically guided transversus abdominis plane block versus local wound infiltration analgesia in laparoscopic surgery for peritoneal endometriosis: A prospective randomized controlled double\u2010blinded\n                    <scp>LTAP<\/scp>\n                    \u2010trial"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3957-3466","authenticated-orcid":false,"given":"Anna M.","family":"Terho","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Research Unit of Clinical Medicine, University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terhi","family":"Puhto","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Medical Research Center Oulu, University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Laru","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Research Unit of Clinical Medicine, University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"Uimari","sequence":"additional","affiliation":[{"name":"Research Unit of Population Health, Faculty of Medicine University of Oulu  Oulu Finland"},{"name":"Medical Research Center Oulu Oulu University Hospital, Wellbeing Services County of North Ostrobothnia  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8245-3000","authenticated-orcid":false,"given":"Pasi","family":"Ohtonen","sequence":"additional","affiliation":[{"name":"Research Service Unit, Oulu University Hospital Wellbeing Services County of North Ostrobothnia, Translational Medicine Research Unit, University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tero","family":"Rautio","sequence":"additional","affiliation":[{"name":"Department of Surgery Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Medical Research Center, University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari","family":"Koivurova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Oulu University Hospital, Wellbeing Services County of North Ostrobothnia, Research Unit of Clinical Medicine, University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.2975"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1810764"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-070750"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.18096"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.590823"},{"key":"e_1_2_13_7_1","unstructured":"ESHRE Endometriosis Guideline Development Group.Endometriosis [Internet].2022. 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