{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:07:13Z","timestamp":1783836433882,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,8]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n To assess longitudinal changes in serum sFlt\u20101 and PLGF in women with newly diagnosed hypertension in pregnancy before and after commencing antihypertensive therapy, aiming at tight BP control (<135\/85\u2009mmHg).<\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n This was a prospective study that assessed women at presentation with hypertension and after 1 and 2\u2009weeks of antihypertensive therapy. At each visit, blood pressure (BP) and blood tests to obtain levels of sFlt\u20101 and PLGF were taken. A multilevel linear mixed\u2010effects model was performed to compare the repeated measurements of sFlt\u20101 and PLGF, controlling for maternal demographics, diagnosis at presentation, and antihypertensive agent used. The cohort was further subdivided into two groups based on how quickly they achieved target BP control to assess whether the degree of initial control influenced the angiogenic profile. Group 1 achieved BP\u2009<\u2009135\/85 after 1\u2009week, while group 2 after 2\u2009weeks of treatment.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 133 women were recruited into the study, 47 in group 1 and 86 in group 2. For the total cohort, both systolic blood pressure (SBP) and diastolic blood pressure (DBP) dropped after 1\u2009week on antihypertensive medication (\n p<\/jats:italic>\n \u2009<\u20090.001) and remained stable thereafter. Log\n 10<\/jats:sub>\n PLGF demonstrated a continuous fall (p\u2009<\u20090.001) while Log\n 10<\/jats:sub>\n sFlt\u20101 did not change after 1 and 2\u2009weeks on medication.\n <\/jats:p>\n \n Group 1 had persistently higher Log\n 10<\/jats:sub>\n PLGF than group 2 (\n p<\/jats:italic>\n \u2009=\u20090.015). Both groups showed a reduction in Log\n 10<\/jats:sub>\n PLGF at a similar rate over 2\u2009weeks on antihypertensive medication. There was no difference between groups throughout the study in Log\n 10<\/jats:sub>\n sFlt\u20101 and no change over time. There was a significant interaction between groups for SBP and DBP (\n p<\/jats:italic>\n \u2009<\u20090.001) but no interaction between groups for Log\n 10<\/jats:sub>\n PLGF or Log\n 10<\/jats:sub>\n sFlt\u20101.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In pregnant women with new\u2010onset hypertension, tight BP control leads to a reduction in SBP and DBP within the first week of antihypertensive treatment. Log\n 10<\/jats:sub>\n PLGF declines, but Log\n 10<\/jats:sub>\n sFlt\u20101 shows no change with time. Women who achieved BP control within 1\u2009week, compared to 2\u2009weeks from commencing treatment, had higher Log\n 10<\/jats:sub>\n PLGF but no difference in Log\n 10<\/jats:sub>\n sFlt\u20101. Both groups demonstrated similar changes, with Log\n 10<\/jats:sub>\n PLGF declining but Log\n 10<\/jats:sub>\n sFlt\u20101 remaining static with time.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aogs.70221","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:37:39Z","timestamp":1778737059000},"page":"1515-1522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of antihypertensive treatment on longitudinal changes in\n PLGF<\/scp>\n and\n sFlt<\/scp>\n \u20101 in women with new onset hypertension in pregnancy"],"prefix":"10.1111","volume":"105","author":[{"given":"Edward","family":"Tyrell","sequence":"first","affiliation":[{"name":"Antenatal Hypertension Clinic King's College Hospital London UK"},{"name":"King's College London University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine G. Y.","family":"Lau","sequence":"additional","affiliation":[{"name":"Antenatal Hypertension Clinic King's College Hospital London UK"},{"name":"King's College London University of London London UK"},{"name":"Fetal Medicine Research Institute King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martyna","family":"Bednorz","sequence":"additional","affiliation":[{"name":"Antenatal Hypertension Clinic King's College Hospital London UK"},{"name":"Fetal Medicine Research Institute King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kypros H.","family":"Nicolaides","sequence":"additional","affiliation":[{"name":"King's College London University of London London UK"},{"name":"Fetal Medicine Research Institute King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos A.","family":"Kametas","sequence":"additional","affiliation":[{"name":"Antenatal Hypertension 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