{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:51:53Z","timestamp":1789487513798,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The objective of this study is to evaluate, in fetuses with early\u2010onset fetal growth\u2010restricted (FGR) requiring delivery before 30\u2009weeks, the relationship between the longitudinal Doppler changes and severe morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>A retrospective cohort was constructed of singleton pregnancies between January 2013 and December 2021 with antenatal suspicion of FGR, born before 30\u2009weeks in a single tertiary center in Barcelona (Hospital Sant Joan de D\u00e9u and Hospital Cl\u00ednic). A total of 103 cases of FGR fetuses were included. Accurate anatomical examination, fetal biometry, and prenatal Doppler ultrasound examination were performed by experienced operators. The association between the intervals from diagnosis to abnormal Doppler and severe adverse outcome was evaluated with Cox and logistic regression, adjusted for gestational age at onset and preeclampsia. The primary outcome was a composite of severe adverse outcomes defined as mortality or severe neurological morbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 83 pregnancies with ductus venosus (DV) pulsatility index (PI) \u226495th centile at admission, the median time to a DV PI &gt;95th centile was 16\u2009days in pregnancies presenting severe adverse outcomes and 20\u2009days in those without (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). Among the 64 pregnancies with a positive umbilical artery (UA) end\u2010diastolic velocity (EDV), the median time to be absent\/reversed was 11\u2009days in pregnancies presenting severe adverse outcome and 14\u2009days in those without (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016). Among the 86 pregnancies with nonreversed UA EDV, the median time to reversed flow was 18\u2009days in pregnancies destined to present severe outcomes and 26\u2009days in those without (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The prediction of mortality or severe morbidity could be better achieved with longitudinal Doppler assessment in FGR fetuses born before 30\u2009weeks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70246","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T07:46:20Z","timestamp":1785829580000},"page":"1965-1973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Doppler assessment and perinatal outcomes in early\u2010set intrauterine growth restriction fetuses"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0069-7640","authenticated-orcid":false,"given":"Edurne","family":"Mazarico","sequence":"first","affiliation":[{"name":"Hospital Sant Joan de D\u00e9u BCNatal  Barcelona Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u  Esplugues de Llobregat Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS), RD24\/0013\/0001 Instituto de Salud Carlos III  Madrid Spain"},{"name":"Departament de Ci\u00e8ncies Cl\u00edniques, Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat de Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Meler","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona Seu Maternitat, BCNatal  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Peguero","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona Seu Maternitat, BCNatal  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edda","family":"Marimon","sequence":"additional","affiliation":[{"name":"Hospital Sant Joan de D\u00e9u BCNatal  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Prat","sequence":"additional","affiliation":[{"name":"Hospital Sant Joan de D\u00e9u BCNatal  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Boada","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona Seu Maternitat, BCNatal  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hospital Sant Joan de D\u00e9u BCNatal  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Contreras","sequence":"additional","affiliation":[{"name":"Hospital Sant Joan de D\u00e9u BCNatal  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Pumarola","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednic de Barcelona Seu Maternitat, BCNatal  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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