{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:07:19Z","timestamp":1783836439835,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN 21 1408 PJ"],"award-info":[{"award-number":["CAN 21 1408 PJ"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN 21\u2010848 PJ"],"award-info":[{"award-number":["CAN 21\u2010848 PJ"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Opportunistic salpingectomy during benign hysterectomy with ovarian preservation has become a preventive approach to epithelial ovarian cancer, particularly high\u2010grade serous carcinoma, given evidence that it originates in the Fallopian tubes. However, the long\u2010term impact of the procedure on ovarian function remains unknown. This study assessed whether opportunistic salpingectomy at benign hysterectomy affects ovarian function compared with no salpingectomy 1\u2009year after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      This is a noninferiority substudy of the national register\u2010based randomized controlled trial HOPPSA (Hysterectomy and OPPortunistic SAlpingectomy), registered at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      (NCT03045965) on 8 February 2017. Women under 55\u2009years planned for a benign hysterectomy at the Sahlgrenska University Hospital were randomized to hysterectomy with opportunistic salpingectomy or hysterectomy\u2010only. Blood samples were collected preoperatively and 1\u2009year postoperatively and analyzed for anti\u2010M\u00fcllerian hormone (AMH) by Access2 immunoassay. The primary outcome was absolute change in AMH over time in the per\u2010protocol population. Secondary outcomes were the relative change in AMH and level of AMH 1\u2009year after surgery. The difference between groups was estimated by analysis of covariance, adjusted for baseline AMH, age groups, operative route, and time from surgery to second sampling. Multiple imputation was applied on missing samples. The noninferiority margin was set to 0.125\u2009\u03bcg\/L.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between 16 August 2018 and 6 September 2023, 89 women were randomized to hysterectomy with opportunistic salpingectomy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200946) or hysterectomy\u2010only (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943). After exclusions due to prior ovarian surgery or not receiving the allocated surgery, 37 women were analyzed in each group. Mean age was 45.1 and 46.3\u2009years in respective groups and mean body mass index was 29.5 and 27.2\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Baseline characteristics did not differ between the groups. Both groups had reduced AMH levels 1\u2009year postoperatively. The adjusted mean difference in the reduction was \u22120.03\u2009\u03bcg\/L (95% CI \u22120.23 to 0.18), with 0.18 exceeding the predefined noninferiority limit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Noninferiority was not demonstrated for opportunistic salpingectomy at hysterectomy compared with hysterectomy\u2010only regarding ovarian function assessed by AMH. Absolute reduction in AMH levels appeared to be similar in both groups, with an unexpectedly large variability in AMH reduction suggesting a more pronounced decline in some individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70247","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:26:42Z","timestamp":1779258402000},"page":"1480-1489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of opportunistic salpingectomy at hysterectomy on anti\u2010M\u00fcllerian hormone: A substudy of a randomized trial"],"prefix":"10.1111","volume":"105","author":[{"given":"Anna","family":"Darelius","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Region V\u00e4stra G\u00f6taland, Department of Obstetrics and Gynecology Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Idahl","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Obstetrics and Gynecology Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Sundfeldt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Region V\u00e4stra G\u00f6taland, Department of Obstetrics and Gynecology Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Strandell","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"},{"name":"Region V\u00e4stra G\u00f6taland, Department of Obstetrics and Gynecology Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1000"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63708-X"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12516"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju410"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.10.016"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20210219"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.04.028"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-04578-5"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14601"},{"issue":"8","key":"e_1_2_14_11_1","article-title":"Hysterectomy with opportunistic salpingectomy versus hysterectomy alone","volume":"8","author":"Lieshout LAM","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg411"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2007.00669.x"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/13697137.2015.1020484"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg066"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2009.08.003"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90075-6"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2022.08.002"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa513"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem105"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-018-3083-8"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2013.03.023"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001398"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14182"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.12.025"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10397-017-1019-z"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.07.1997"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2017.09.012"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.02.005"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem101"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.07.1139"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew112"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00724"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmac045"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2019.7733"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmae004"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa436"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.70247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:17:50Z","timestamp":1783833470000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.70247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,19]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/aogs.70247"],"URL":"https:\/\/doi.org\/10.1111\/aogs.70247","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,19]]},"assertion":[{"value":"2025-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}