{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:07:18Z","timestamp":1783836438413,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003123","name":"Fetal Medicine Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003123","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011033","name":"Thermo Fisher Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,8]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n There is a lack of published data on how healthcare professionals perceive the acceptability of third\u2010trimester risk screening in pregnancy. The PREVENT\u2010PE trial [ISRCTN41632964] demonstrated that a personalized approach to term pre\u2010eclampsia risk assessment to inform risk\u2010stratified timed birth at term reduced the incidence of term PE by 30%, without increasing Cesarean birth or neonatal morbidity. We aimed to evaluate the acceptability of the PREVENT\u2010PE trial among healthcare professionals.<\/jats:p>\n <\/jats:sec>\n \n Material and Methods<\/jats:title>\n Staff were invited to an online survey comprising validated metrics of acceptability, which were analyzed descriptively. Also, the staff were invited to one\u2010to\u2010one interviews to probe the acceptability of the trial in more depth. Using template analysis, responses were mapped onto the following domains of acceptability: Sense\u2010making (Intervention Coherence), Commitment (Affective Attitude), Change (Burden), Communication (Ethicality), Motivation (Opportunity Costs), Action (Self\u2010Efficacy), and Evaluation (Perceived Effectiveness).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n There were 65 completed surveys, whilst 19 healthcare professionals participated in interviews. Forty\u2010one staff participants were from King's College Hospital, and twenty\u2010one staff participants were from Medway Maritime Hospital, in line with the recruitment of participants to the trial. Approximately 29% of staff were of non\u2010White ethnicity. Most staff were doctors or midwives, in similar proportions. One\u2010third of staff participants had no prior involvement in clinical trials. Acceptability was endorsed by the majority of survey respondents (69.2%), as \u201cvery acceptable\u201d (44.6%) or \u201csomewhat acceptable\u201d (24.6%). Interview findings endorsed acceptability from most staff toward participating in an evidence\u2010based trial such as PREVENT\u2010PE. Despite some concerns about implementation burden, system\u2010level readiness, and counseling high\u2010risk participants, the staff supported integrating such screening into routine maternity care if effectiveness is confirmed.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The PREVENT\u2010PE trial had a high level of acceptability among healthcare professionals. Staff view risk screening in the third trimester of pregnancy as acceptable, with potential to positively impact patient outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/aogs.70249","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:16:28Z","timestamp":1779783388000},"page":"1542-1552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Healthcare professionals' perceptions of the acceptability of the\n PREVENT<\/scp>\n \u2010\n PE<\/scp>\n trial: A mixed\u2010methods survey and interview study"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3391-5380","authenticated-orcid":false,"given":"Angel","family":"Leung","sequence":"first","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5381-1670","authenticated-orcid":false,"given":"James","family":"Goadsby","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"},{"name":"Department of Women & Children's Health, School of Life Course & Population Health Sciences King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1254-1763","authenticated-orcid":false,"given":"Kayleigh S.","family":"Sheen","sequence":"additional","affiliation":[{"name":"Department of Women & Children's Health, School of Life Course & Population Health Sciences King's College London London UK"},{"name":"Department of Social Sciences, College of Health, Science and Society University of the West of England Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7177-3471","authenticated-orcid":false,"given":"Sergio A.","family":"Silverio","sequence":"additional","affiliation":[{"name":"Department of Women & Children's Health, School of Life Course & Population Health Sciences King's College London London UK"},{"name":"Department of Psychology, Institute of Population Health University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1355-610X","authenticated-orcid":false,"given":"Laura A.","family":"Magee","sequence":"additional","affiliation":[{"name":"Department of Women & Children's Health, School of Life Course & Population Health Sciences King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4136-3070","authenticated-orcid":false,"given":"Peter","family":"von Dadelszen","sequence":"additional","affiliation":[{"name":"Department of Women & Children's Health, School of Life Course & Population Health Sciences King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-6072","authenticated-orcid":false,"given":"Argyro","family":"Syngelaki","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"},{"name":"Department of Women & Children's Health, School of Life Course & Population Health Sciences King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1266-0711","authenticated-orcid":false,"given":"Kypros H.","family":"Nicolaides","sequence":"additional","affiliation":[{"name":"Harris Birthright Research Centre for Fetal Medicine King's College Hospital London UK"},{"name":"Department of Women & Children's Health, School of Life Course & Population Health Sciences King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2103372"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17342"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704559"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23704"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800566"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)01207-3"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.70230"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1234\/hospitals.v2i1.1"},{"issue":"4","key":"e_1_2_14_10_1","first-page":"345","article-title":"The importance of clinical staff involvement in clinical trials","volume":"28","author":"Harris M","year":"2019","journal-title":"J Clin Res"},{"issue":"2","key":"e_1_2_14_11_1","first-page":"234","article-title":"Improving participant recruitment and retention in clinical trials: hospital staff perspectives","volume":"13","author":"Miller A","year":"2017","journal-title":"Clinical Trials Review"},{"issue":"2","key":"e_1_2_14_12_1","first-page":"105","article-title":"Staff engagement and its influence on clinical trial success","volume":"30","author":"Eisenstein EL","year":"2017","journal-title":"J Clin Trials"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1197\/jamia.M1748"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2025.101211"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-017-2031-8"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-022-07696-0"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14780887.2014.955224"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.4135\/9781526435620.n24"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgwh.2022.936770"},{"key":"e_1_2_14_20_1","unstructured":"Royal College of Midwives.RCM position statement on normal birth.2017.https:\/\/www.rcm.org.uk\/media\/rcm\u2010position\u2010statement\u2010normal\u2010birth\u20102017.pdf"},{"key":"e_1_2_14_21_1","unstructured":"Royal College of Obstetricians and Gynaecologists.Each baby counts: 2020 final progress report.2021.https:\/\/www.rcog.org.uk\/media\/a4eg2xnm\/ebc\u20102020\u2010final\u2010progress\u2010report.pdf"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70249","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.70249","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:17:48Z","timestamp":1783833468000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.70249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/aogs.70249"],"URL":"https:\/\/doi.org\/10.1111\/aogs.70249","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"2025-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}