{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T06:43:45Z","timestamp":1786171425890,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Seromucinous borderline ovarian tumors represent a distinct borderline ovarian tumor histotype, yet their specific sonographic features and clinical associations remain undercharacterized. The objective of this study was to describe the ultrasound and clinical characteristics of seromucinous borderline ovarian tumors compared to other borderline tumor histotypes and to evaluate their association with endometriosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This single\u2010center observational retrospective cohort study was conducted at a tertiary\u2010level reference ultrasound unit. The primary outcome was to analyze the clinical and ultrasound characteristics of seromucinous borderline ovarian tumors compared to other histotypes. The secondary outcome was to evaluate their association with different endometriotic lesions. In women with borderline ovarian tumors, anamnestic data (age, body mass index, parity, menopausal status), preoperative serum carbohydrate antigens 125 and carbohydrate antigen 19.9 levels, ultrasound characteristics (according to the International Ovarian Tumor Analysis group), surgery type, and histological data, including endometriosis localization (superficial, deep, or ovarian), were extracted from medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 151 women with borderline ovarian tumors, five had rare histotypes and were excluded. Of the 146 included women, 96 (63.6%) had a serous histotype, 27 (17.9%) a mucinous histotype, and 23 (15.2%) had a seromucinous histotype. Seromucinous borderline ovarian tumors were more commonly left\u2010sided, unilateral unilocular or multilocular solid cysts, with ground\u2010glass content, showing moderate vascularization at color Doppler examination (Color Score 3) of papillary projections\/solid component. Moreover, they had higher preoperative levels of carbohydrate antigen 19.9 compared to other histotypes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Endometriosis was detected in 26% of all study women but was significantly more frequent (70%) in women with seromucinous borderline ovarian tumors (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared to other histotypes, seromucinous borderline ovarian tumors appeared more commonly as left unilateral unilocular or multilocular solid cysts, with ground\u2010glass content, showing moderate vascularization of papillary projections\/solid component. Moreover, they showed a higher increase in serum carbohydrate antigen 19.9 and were associated with endometriosis in most cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70254","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T08:53:21Z","timestamp":1779785601000},"page":"1860-1870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seromucinous borderline ovarian tumors: Clinical and ultrasound characteristics and association with endometriosis"],"prefix":"10.1111","volume":"105","author":[{"given":"Simona","family":"Del Forno","sequence":"first","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8151-0947","authenticated-orcid":false,"given":"Marisol","family":"Doglioli","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences, DIMEC University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Landolfo","sequence":"additional","affiliation":[{"name":"Queen Charlotte's and Chelsea Hospital Imperial College Healthcare NHS Trust  London UK"},{"name":"Department of Metabolism, Digestion &amp; Reproduction, Faculty of Medicine Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6039-6163","authenticated-orcid":false,"given":"Giovanna","family":"Palomba","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences, DIMEC University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Vicenzi","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, DIMEC University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"De Meis","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Govoni","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Paradisi","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3235-4378","authenticated-orcid":false,"given":"Diego","family":"Raimondo","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Seracchioli","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Human Reproduction Physiopathology IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Department of Medical and Surgical Sciences, DIMEC University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0489-8_14"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2002.01152.x"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-1-70"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12276"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23724"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000282"},{"key":"e_1_2_14_8_1","volume-title":"WHO Classification of Tumours of Female Reproductive Organs","author":"Kurman RJIA for R on CWHO","year":"2014"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-016-2040-8"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2017.08.661"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1823"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11149"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2607"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-07113-z\/Published"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.16756"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10020077"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_14_18_1","doi-asserted-by":"crossref","unstructured":"European Federation of Societies for Ultrasound in Medicine and Biology.Ultraschall in der Medizin \u2010 European journal of ultrasound.2006;27(1):79\u2010105. doi:10.1055\/s-2006-933605","DOI":"10.1055\/s-2006-933605"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2013.10.001"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.2000.00287.x"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2018.29.e28"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-022-01114-7"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340701671929"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-024-01489-9"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/life14060704"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2025.102367"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000475817"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7668"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.mp.2017-0055"},{"issue":"3","key":"e_1_2_14_30_1","first-page":"382","article-title":"Clinical and ultrasound features of benign, borderline, and malignant invasive mucinous ovarian tumors","volume":"38","author":"Pascual A","year":"2017","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11092414"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.70254","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T06:05:33Z","timestamp":1786169133000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.70254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/aogs.70254"],"URL":"https:\/\/doi.org\/10.1111\/aogs.70254","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"2026-02-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}