{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T06:43:47Z","timestamp":1786171427540,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2023A04J1803"],"award-info":[{"award-number":["2023A04J1803"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Anti\u2010\n                      <jats:italic>N<\/jats:italic>\n                      \u2010methyl\u2010D\u2010aspartate receptor (anti\u2010NMDAR) encephalitis predominantly affects women of reproductive age and is frequently associated with ovarian teratomas. While acute neurological outcomes are well described, the long\u2010term impact on ovarian endocrine function and fertility\u2014particularly in tumor\u2010associated cases\u2014remains poorly understood, creating significant uncertainty in survivorship counseling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study involving 106 women diagnosed with anti\u2010NMDAR encephalitis at a tertiary academic hospital between 2015 and 2024. Primary outcomes included the recovery of ovarian endocrine function, measured by serial sex hormone levels and fertility outcomes. Secondary analyses assessed disease severity, tumor markers, and neuroimaging features between teratoma\u2010associated cases and non\u2010teratoma cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with teratoma\u2010associated encephalitis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923) exhibited greater acute disease severity, necessitating higher rates of ICU admission (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012) and mechanical ventilation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021). During the acute phase of illness, 38% of all patients experienced HPO axis suppression, primarily manifesting as amenorrhea. However, longitudinal monitoring revealed substantial recovery, with significant improvements in both luteinizing hormone (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and estradiol levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) during convalescence. Notably, pregnancy rates were comparable between the teratoma (80%) and non\u2010teratoma (83.3%) groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.68).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ovarian dysfunction in anti\u2010NMDAR encephalitis is often reversible, and long\u2010term fertility remains favorable even in teratoma\u2010associated cases. These findings provide valuable guidance for fertility counseling and highlight the importance of incorporating reproductive health monitoring into the long\u2010term care of young women with tumor\u2010related autoimmune encephalitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70261","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:05:22Z","timestamp":1780981522000},"page":"1823-1832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fertility outcomes and ovarian function recovery after anti\u2010\n                    <scp>NMDAR<\/scp>\n                    encephalitis: A retrospective cohort study"],"prefix":"10.1111","volume":"105","author":[{"given":"Jia","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gynecology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou Guangdong Province 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