{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T06:43:50Z","timestamp":1786171430028,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Uterine fibroids are common benign neoplasms in women. Magnetic resonance\u2010guided high\u2010intensity focused ultrasound (MR\u2010HIFU) is a noninvasive treatment that has been shown to reduce fibroid\u2010related symptoms and improve quality of life (QoL). In this study, we aimed to clarify symptom reduction in patients with isolated bleeding or bulk symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>\n                      This prospective study with a 12\u2010month follow\u2010up included 163 women with uterine fibroids causing either bleeding or bulk symptoms and deemed suitable for MR\u2010HIFU treatment. Treatments were carried out using an extracorporeal tabletop MR\u2010HIFU system (Sonalleve V2, Profound Medical Inc., Mississauga, Canada). The non\u2010perfused volume ratio (NPV%) was determined after treatment. Symptom severity and QoL were assessed using the Uterine Fibroid Symptom and Quality of Life questionnaire at baseline, 3\u2009months, and 12\u2009months after treatment. The study was registered at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      (NCT02914704).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 122 women with bleeding and 41 women with bulk symptoms were included. The overall mean NPV% for all patients was 62%. The median symptom severity score (SSS) at baseline was 56 (IQR 47\u201369) and 46 (34\u201363), at 3\u2009months 28 (16\u201344) and 19 (6\u201330), and at 12\u2009months 25 (13\u201331) and 19 (6\u201341) for the bleeding and bulk groups, respectively. The reduction of SSS was statistically significant between baseline and 3\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and between baseline and 12\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in both groups. The median of QoL at baseline was 43 (IQR 31\u201358) and 74 (45\u201383), at 3\u2009months 70 (53\u201382) and 89 (74\u201397), and at 12\u2009months 82 (69\u201391) and 82 (67\u2013100) for the bleeding and bulk groups, respectively. In the bleeding patients, the increase in QoL was statistically significant between all the time points compared (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In the bulk group, the increase in QoL was statistically significant from baseline to 3\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and from baseline to 12\u2009months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MR\u2010HIFU resulted in significant symptom reduction and improved QoL in patients with both bleeding and bulk\u2010related fibroid symptoms. When successful, MR\u2010HIFU provides effective and rapid symptom relief for both symptom types.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70268","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:24:24Z","timestamp":1781526264000},"page":"1840-1847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnetic resonance\u2010guided high\u2010intensity focused ultrasound (\n                    <scp>MR<\/scp>\n                    \u2010\n                    <scp>HIFU<\/scp>\n                    ) therapy of uterine fibroids effectively reduces both bleeding and bulk symptoms\u2014A prospective single\u2010center 12\u2010month follow\u2010up study"],"prefix":"10.1111","volume":"105","author":[{"given":"Saara","family":"Otonkoski","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Turku University Hospital  Turku Finland"},{"name":"Faculty of Medicine University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Viitala","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Turku  Turku Finland"},{"name":"Department of Radiology Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaber","family":"Komar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Turku  Turku Finland"},{"name":"Department of Radiology Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-2601","authenticated-orcid":false,"given":"Teija","family":"Sainio","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Turku  Turku Finland"},{"name":"Department of Medical Physics Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Yanovskiy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Turku  Turku Finland"},{"name":"Department of Radiology Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Lehtonen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Turku University Hospital  Turku Finland"},{"name":"Faculty of Medicine University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Blanco Sequeiros","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Turku  Turku Finland"},{"name":"Department of Radiology Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Perheentupa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Turku University Hospital  Turku Finland"},{"name":"Faculty of Medicine University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsi","family":"Joronen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Turku University Hospital  Turku Finland"},{"name":"Faculty of Medicine University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14640"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000164"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2024.04.041"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1607264"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2022.102355"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2019.03.021"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2021.03.013"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2010.11.011"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnab039"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmw023"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13102"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.06.051"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20220121"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.05.020"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2019.108700"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3538-6"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-014-3295-6"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2011.03.008"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2024.02.005"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.15086"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200202000-00021"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2020.1846792"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2021.09.005"}],"container-title":["Acta Obstetricia et Gynecologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70268","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aogs.70268","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aogs.70268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T06:05:52Z","timestamp":1786169152000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/aogs.70268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/aogs.70268"],"URL":"https:\/\/doi.org\/10.1111\/aogs.70268","archive":["Portico"],"relation":{},"ISSN":["0001-6349","1600-0412"],"issn-type":[{"value":"0001-6349","type":"print"},{"value":"1600-0412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]},"assertion":[{"value":"2026-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}