{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:50:11Z","timestamp":1789487411624,"version":"build-2803163510"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2704103"],"award-info":[{"award-number":["2022YFC2704103"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2023YFS0046"],"award-info":[{"award-number":["2023YFS0046"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Uterine leiomyomata are the most common neoplasms among women of reproductive age. Laparoscopic myomectomy is desirable for patients who wish to preserve their fertility or retain their uterus. There lacks a large\u2010scale study to compare the surgical safety between transumbilical laparoendoscopic single\u2010site surgery (single\u2010site laparoscopy) and conventional multi\u2010port laparoscopy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>This registered retrospective observational study (MR\u201051\u201023\u2010020457, ChiCTR) included patients with leiomyomata who underwent single\u2010site laparoscopy or multi\u2010port laparoscopy for myomectomy. The patients' characteristics, perioperative outcomes, obstetric outcomes, and satisfaction scores for the incision were recorded and analyzed between the two groups. The primary outcome was the incidence of intraoperative adverse events, including organ injury and bleeding, and the secondary outcomes were Enhanced Recovery After Surgery indicators, including surgery\u2010related pain, flatulence time, postoperative hospital stay, and cosmetic satisfaction of incisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1437 single\u2010site laparoscopy and 2514 multi\u2010port laparoscopy patients were included. The incidence of Grade I intraoperative adverse events (organ injury) was 0.70% in single\u2010site laparoscopy and 0.44% in multi\u2010port laparoscopy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.624), the Grade II intraoperative adverse events (bleeding requiring blood transfusion) were 6.75% in single\u2010site laparoscopy and 6.24% in multi\u2010port laparoscopy (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.533). Single\u2010site laparoscopy patients had shorter postoperative hospital stay (2.21\u2009\u00b1\u20091.18 vs. 2.70\u2009\u00b1\u20091.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and lower surgery\u2010related pain score (2.82\u2009\u00b1\u20090.58 vs. 2.89\u2009\u00b1\u20090.63,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Besides, patients from single\u2010site laparoscopy had a higher satisfaction score for incisional healing (4.60\u2009\u00b1\u20090.62 vs. 4.43\u2009\u00b1\u20090.66,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) than those from the multi\u2010port laparoscopy group. Additionally, seven single\u2010site laparoscopy patients and nine multi\u2010port laparoscopy patients were diagnosed with uterine sarcoma. During the second surgery, the isolated and minor pelvic implantation found in one patient (0.5\u2009\u00d7\u20090.5\u2009cm) from the single\u2010site laparoscopy group had a smaller size and narrower distribution than that found in the three patients (1.0\u2009\u00d7\u20091.0\u2009cm, 3.0\u2009\u00d7\u20093.0\u2009cm,3.0\u2009\u00d7\u20093.0\u2009cm) from the multi\u2010port laparoscopy group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings support the notion that single\u2010site laparoscopy and multi\u2010port laparoscopy for myomectomy show similar performance in terms of surgical safety. Single\u2010site laparoscopy outperforms multi\u2010port laparoscopy with respect to postoperative hospital stays and cosmetic satisfaction with the incision.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70309","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:42:04Z","timestamp":1784022124000},"page":"2068-2080","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transumbilical laparoendoscopic single\u2010site surgery versus conventional multi\u2010port laparoscopy for myomectomy: A large single\u2010center retrospective study"],"prefix":"10.1111","volume":"105","author":[{"given":"Xu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second University Hospital, Sichuan University  Chengdu China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) 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