{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:59:49Z","timestamp":1785315589454,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Acta Obstet Gynecol Scand"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Preeclampsia is known to be associated with a two\u2010 to fourfold elevated risk of developing cardiovascular disease in the first 15\u2009years following pregnancy. In this cross\u2010sectional study of 892 women with prior preeclampsia, we aimed to assess differences in circulating angiogenic biomarker concentrations according to CT\u2010assessed coronary atherosclerosis in women up to 28\u2009years after an index pregnancy complicated by preeclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Women were identified from clinical databases consisting of data from all deliveries within the Capital Region of Denmark from 1995 onwards. Women with prior preeclampsia and a current age between 35 and 55\u2009years were included from the CPH\u2010PRECIOUS cohort. The primary outcome was differences in circulating angiogenic biomarkers according to CT\u2010assessed coronary atherosclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median time since the pregnancy complicated by preeclampsia was 12.5\u2009years (range: 0\u201328\u2009years). PlGF concentrations were significantly higher in women with coronary atherosclerosis (9.6\u2009pg\/mL [IQR 4.9\u201312.6] vs. 7.4\u2009pg\/mL [IQR 3.9\u201311.3],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and subsequently a lower calculated sFlt\u20101\/PlGF ratio (4.2 [IQR 3.1\u20136.3] vs. 5.0 [IQR 3.6\u20136.9],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) was found. No differences in sFlt\u20101 concentrations were observed. Higher PlGF concentrations were significantly associated with coronary atherosclerosis; however, associations were attenuated in adjusted analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first large study to investigate long\u2010term differences in circulating angiogenic biomarker concentrations after preeclampsia, highlighting the complex relationship between angiogenic biomarkers, preeclampsia, and later atherosclerotic burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aogs.70322","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:11:42Z","timestamp":1785312702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Angiogenic biomarker concentrations and their relation to coronary atherosclerosis in women with a history of preeclampsia: Findings from the\n                    <scp>CPH<\/scp>\n                    \u2010\n                    <scp>PRECIOUS<\/scp>\n                    study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4693-6352","authenticated-orcid":false,"given":"Signe H\u00f8jstrup","family":"Bessing","sequence":"first","affiliation":[{"name":"Department of Gynaecology, Fertility and Obstetrics, Juliane Marie Center Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Guldbrandt","family":"Hauge","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Fertility and Obstetrics, Juliane Marie Center Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2101-5098","authenticated-orcid":false,"given":"Jesper James","family":"Linde","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Center Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Fertility and Obstetrics, Juliane Marie Center Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Ersb\u00f8ll","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Fertility and Obstetrics, Juliane Marie Center Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9742-1554","authenticated-orcid":false,"given":"Klaus Fuglsang","family":"Kofoed","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Cardiology and Radiology Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Center Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Cardiology Copenhagen University Hospital, Amager and Hvidovre  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Ejlstrup","family":"Sigvardsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Center Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2144-341X","authenticated-orcid":false,"given":"Finn","family":"Gustafsson","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Heart Center Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3119-017X","authenticated-orcid":false,"given":"Mille","family":"Kirk","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Biochemistry Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9080-3389","authenticated-orcid":false,"given":"Line","family":"Rode","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Biochemistry Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2067-5246","authenticated-orcid":false,"given":"Peter","family":"Damm","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Fertility and Obstetrics, Juliane Marie Center Rigshospitalet, Copenhagen University Hospital  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen 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