{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T09:15:08Z","timestamp":1697447708385},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T00:00:00Z","timestamp":1365724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The majority of cases involving the surgical treatment of congenital heart disease require implementation of cardiopulmonary bypass (<jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>). However, neonates and infants are particularly prone to serious complications associated with <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> as a result of capillary leak due to cardiovascular failure. These complications are related to the transfusion of foreign blood, the disproportionately large area of contact between the patient's blood and foreign material, as well as the systemic inflammatory response induced by hemolysis. To attenuate these risks, we developed a novel, highly integrative, miniaturized heart\u2010lung machine (<jats:styled-content style=\"fixed-case\">MiniHLM<\/jats:styled-content>) with a static priming volume of only 102\u2009mL. This prototype was tested in comparison with a conventional heart\u2010lung machine (static priming volume 213\u2009m<jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>) using a rabbit animal model. The animals were anesthetized, sternotomized, and connected to <jats:styled-content style=\"fixed-case\">CBP<\/jats:styled-content> via the aorta and right atrium. The aorta was cross\u2010clamped for 1\u2009h. Blood samples for examination were taken at regular intervals. Biopsies of the right atrial appendage (<jats:styled-content style=\"fixed-case\">RAA<\/jats:styled-content>) were removed directly after initiation and after cessation of <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>. After gradual reduction of perfusion with the <jats:styled-content style=\"fixed-case\">HLM<\/jats:styled-content>, all rabbits were successfully weaned from <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>, and the sternum was closed. Foreign blood was not administered in all cases. After cryopreservation of the <jats:styled-content style=\"fixed-case\">RAA<\/jats:styled-content> tissue, de novo transcription of inflammatory cytokines was measured by means of real\u2010time polymerase chain reaction using the comparative <jats:styled-content style=\"fixed-case\">C<jats:sub>T<\/jats:sub><\/jats:styled-content> method. No significant differences in the expression of the inflammatory parameters of the myocardial tissue samples were found between the study groups.<\/jats:p>","DOI":"10.1111\/aor.12025","type":"journal-article","created":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T07:28:42Z","timestamp":1365751722000},"page":"541-548","source":"Crossref","is-referenced-by-count":2,"title":["Expression of Inflammation in Myocardial Tissue of Rabbits: Comparison of Two Miniaturized Heart\u2010Lung Machines"],"prefix":"10.1111","volume":"37","author":[{"given":"Heike","family":"Schnoering","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiac Surgery Medical Faculty RWTH Aachen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutta","family":"Arens","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute RWTH Aachen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine M.","family":"Detering","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery Medical Faculty RWTH Aachen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg S.","family":"Sachweh","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery Medical Faculty RWTH Aachen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Goetzenich","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Medical Faculty RWTH Aachen University  Aachen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Schmitz\u2010Rode","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute RWTH Aachen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Steinseifer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Helmholtz Institute RWTH Aachen University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime F.","family":"Vazquez\u2010Jimenez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiac Surgery Medical Faculty RWTH Aachen 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