{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:42:26Z","timestamp":1773481346682,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T00:00:00Z","timestamp":1364860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Total hip arthroplasty (<jats:styled-content style=\"fixed-case\">THA<\/jats:styled-content>) can be achieved by using a cemented or noncemented prosthesis. Besides patient's age, weight, and other clinical signs, the evaluation of the quality of the bones is a crucial parameter on which orthopedic surgeons base the choice between cemented and noncemented <jats:styled-content style=\"fixed-case\">THA<\/jats:styled-content>. Although bone density generally decreases with age and a cemented <jats:styled-content style=\"fixed-case\">THA<\/jats:styled-content> is preferred for older subjects, the bone quality of a particular patient should be quantitatively evaluated. This study proposes a new method to quantitatively measure bone density and fracture risk by using 3<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> models extracted by a preoperative computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) scan of the patient. Also, the anatomical structure and compactness of the quadriceps muscle is computed to provide a more complete view. A spatial reconstruction of the tissues is obtained by means of <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> image processing, then a detailed 3<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> model of bone mineral density of the femur is provided by including quantitative <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> density information (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> must be precalibrated). A finite element analysis will provide a map of the strains around the proximal femur socket when solicited by typical stresses caused by an implant. The risk for structural failure due to press\u2010fitting and compressive stress during noncemented <jats:styled-content style=\"fixed-case\">THA<\/jats:styled-content> surgery was estimated by calculating a bone fracture risk index (ratio between actual compressive stress and estimated failure stress of the bone). A clinical trial was carried out including 36 volunteer patients (ages 22\u201377) who underwent unilateral <jats:styled-content style=\"fixed-case\">THA<\/jats:styled-content> surgery for the first time: 18 received a cemented implant and 18 received a noncemented implant. <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> scans were acquired before surgery, immediately after, and after 12 months. Bone and quadriceps density results were higher in the healthy leg in about 80% of the cases. Bone and quadriceps density generally decrease with age but mineral density may vary significantly between patients. Preliminary results indicate the highest fracture risk at the calcar and the lowest at the intertrocanteric line, with some difference between patients. An analysis of the results suggest that this methodology can be a valid noninvasive decision support tool for <jats:styled-content style=\"fixed-case\">THA<\/jats:styled-content> planning; however, further analyses are needed to tune the technique and to allow clinical applications. Combination with gait analysis data is planned.<\/jats:p>","DOI":"10.1111\/aor.12033","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T03:57:26Z","timestamp":1364961446000},"page":"567-573","source":"Crossref","is-referenced-by-count":16,"title":["Assessment of Total Hip Arthroplasty by Means of <scp>C<\/scp>omputed <scp>T<\/scp>omography 3<scp>D<\/scp> Models and Fracture Risk Evaluation"],"prefix":"10.1111","volume":"37","author":[{"given":"Paolo","family":"Gargiulo","sequence":"first","affiliation":[{"name":"Department of Science, Education and Innovation Landspitali University Hospital  Reykjavik Iceland"},{"name":"Biomedical Engineering Department Reykjavik University  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Throstur","family":"P\u00e9tursson","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department Reykjavik University  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Magn\u00fasson","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department Reykjavik University  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Bifulco","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Electronic and Telecommunication Engineering University Federico II of Naples  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Cesarelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Electronic and Telecommunication Engineering University Federico II of Naples  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca Mario","family":"Izzo","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Electronic and Telecommunication Engineering University Federico II of Naples  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00edgja","family":"Magn\u00fasd\u00f3ttir","sequence":"additional","affiliation":[{"name":"Rehabilitation Clinic Grens\u00e1s, Landspitali Hospital  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gr\u00e9tar","family":"Halld\u00f3rsson","sequence":"additional","affiliation":[{"name":"Rehabilitation Clinic Grens\u00e1s, Landspitali Hospital  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gudbj\u00f6rg K.","family":"Ludvigsd\u00f3ttir","sequence":"additional","affiliation":[{"name":"Rehabilitation Clinic Grens\u00e1s, Landspitali Hospital  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Tribel","sequence":"additional","affiliation":[{"name":"Orthopaedic Clinic Landspitali Hospital  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Halldor","family":"J\u00f3nsson","sequence":"additional","affiliation":[{"name":"Orthopaedic Clinic Landspitali Hospital  Reykjavik Iceland"},{"name":"Medical Faculty Iceland University  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,2]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"154","article-title":"Femoral bone loss in total knee arthroplasty","volume":"65","author":"Loon CJ","year":"1999","journal-title":"Acta Orthop Belg"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1302\/0301-620X.78B3.0780349","article-title":"Porosity reduction in bone cement at the cement\u2010stem interface","volume":"78","author":"Bishop NE","year":"1996","journal-title":"J Bone Joint Surg Br"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-008-1317-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/17453671003685400"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.7.1343"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2011.01214.x"},{"key":"e_1_2_6_8_1","first-page":"324","volume-title":"Handbook of Anthropometry: Physical Measures of Human Form in Health and Disease","author":"Gargiulo P","year":"2012"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2008.00610.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2007.05.006"},{"key":"e_1_2_6_11_1","unstructured":"KwakSD SlivikaM.Biomechanical characterization of cobalt\u2010chromium alloy spinal rods. 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A comparison of gait analysis in unilateral and bilateral cases","volume":"74","author":"Wykman A","year":"1992","journal-title":"J Bone Joint Surg Br"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12033","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T12:53:25Z","timestamp":1697374405000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,2]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/aor.12033"],"URL":"https:\/\/doi.org\/10.1111\/aor.12033","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,2]]}}}