{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T04:24:31Z","timestamp":1745987071620,"version":"3.40.4"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T00:00:00Z","timestamp":1363305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Hemodynamic effects related to changes in serum ionized calcium (<jats:styled-content style=\"fixed-case\">iCa<\/jats:styled-content>) are difficult to determine during conventional hemodialysis (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) using a fixed dialysate concentration of calcium. Regional citrate anticoagulation (<jats:styled-content style=\"fixed-case\">RCA<\/jats:styled-content>) allows the study of the effects of predefined<jats:styled-content style=\"fixed-case\">iCa<\/jats:styled-content>changes on arterial stiffness and blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) during a single dialysis session. In a crossover study, 15 patients with end\u2010stage renal disease underwent two<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>sessions with<jats:styled-content style=\"fixed-case\">RCA<\/jats:styled-content>. Each session was divided into two study phases in which<jats:styled-content style=\"fixed-case\">iCa<\/jats:styled-content>was titrated either to 0.8\u20131.0\u2009m<jats:sc>m<\/jats:sc>or to 1.1\u20131.4\u2009m<jats:sc>m<\/jats:sc>. The sequence of phases was randomly chosen and alternated for the second session. After reaching a stable<jats:styled-content style=\"fixed-case\">iCa<\/jats:styled-content>level, pulse wave velocity (<jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>), arterial<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, and heart rate were measured.<jats:styled-content style=\"fixed-case\">iCa<\/jats:styled-content>levels were modified during sequence 1 (<jats:styled-content style=\"fixed-case\">iCa<\/jats:styled-content>low\u2010high) from a predialysis baseline value of 1.15\u2009\u00b1\u20090.09\u2009m<jats:sc>m<\/jats:sc>, first to 0.92\u2009\u00b1\u20090.05\u2009m<jats:sc>m<\/jats:sc>(time point 1;<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 vs. baseline) and then to 1.18\u2009\u00b1\u20090.05 (time point 2; ns). During sequence 2 (<jats:styled-content style=\"fixed-case\">iCa<\/jats:styled-content>high\u2010low),<jats:styled-content style=\"fixed-case\">iCa<\/jats:styled-content>levels were modified from 1.15\u2009\u00b1\u20090.12\u2009m<jats:sc>m<\/jats:sc>first to 1.20\u2009\u00b1\u20090.05\u2009m<jats:sc>m<\/jats:sc>(time point 1; ns vs. baseline) and then to 0.93\u2009\u00b1\u20090.03 (time point 2;<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Assuming a basic linear repeated measures model,<jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>was positively related to<jats:styled-content style=\"fixed-case\">iCa<\/jats:styled-content>levels (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.03) independent of systolic or diastolic<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, heart rate, or ultrafiltration rate.<jats:styled-content style=\"fixed-case\">PWV<\/jats:styled-content>is closely related to acute changes in serum<jats:styled-content style=\"fixed-case\">iCa<\/jats:styled-content>levels in<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>patients using<jats:styled-content style=\"fixed-case\">RCA<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">RCA<\/jats:styled-content>provides an interesting opportunity to study the effects of acute<jats:styled-content style=\"fixed-case\">iCa<\/jats:styled-content>changes during one dialysis procedure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.12037","type":"journal-article","created":{"date-parts":[[2013,3,16]],"date-time":"2013-03-16T04:17:25Z","timestamp":1363407445000},"page":"467-474","source":"Crossref","is-referenced-by-count":9,"title":["Arterial Stiffness Depends on Serum Ionized Calcium Levels During Dialysis With Regional Citrate Anticoagulation"],"prefix":"10.1111","volume":"37","author":[{"given":"Matthias B.","family":"Moor","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension University Hospital of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Kruse","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University Hospital of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik E.","family":"Uehlinger","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University Hospital of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Eisenberger","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University Hospital of Bern Bern Switzerland"},{"name":"Department of Nephrology University Hospital Essen\u2010Duisburg Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.18.2434"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00932.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.5.1236"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.061"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq582"},{"key":"e_1_2_8_7_1","first-page":"29","article-title":"Factors modulating cytosolic calcium. 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