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The inflow cannulation site induces major hemodynamic changes and so there is a need to optimize the site used depending on the patient's condition. Therefore, this study evaluated and compared the hemodynamic influence of right atrial cannulation (RAC<\/jats:styled-content>) and right ventricular cannulation (RVC<\/jats:styled-content>) inflow sites. An in vitro variable heart failure mock circulation loop was used to compare RAC<\/jats:styled-content> and RVC<\/jats:styled-content> in mild and severe biventricular heart failure (BHF<\/jats:styled-content>) conditions. In the severe BHF<\/jats:styled-content> condition, higher ventricular ejection fraction (RAC<\/jats:styled-content>: 13.6%, RVC<\/jats:styled-content>: 32.7%) and thus improved heart chamber and RVAD<\/jats:styled-content> washout were observed with RVC<\/jats:styled-content>, which suggested this strategy might be preferable for long\u2010term support (i.e., bridge\u2010to\u2010transplant or destination therapy) to reduce the risk of thrombus formation. In the mild BHF<\/jats:styled-content> condition, higher pulmonary valve flow (RAC<\/jats:styled-content>: 3.33\u2009L\/min, RVC<\/jats:styled-content>: 1.97\u2009L\/min) and lower right ventricular stroke work (RAC<\/jats:styled-content>: 0.10\u2009W, RVC<\/jats:styled-content>: 0.13\u2009W) and volumes were recorded with RAC<\/jats:styled-content>. These results indicate an improved potential for myocardial recovery, thus RAC<\/jats:styled-content> should be chosen in this condition. This in vitro study suggests that RVAD<\/jats:styled-content> inflow cannulation site should be chosen on a patient\u2010specific basis with a view to the support strategy to promote myocardial recovery or reduce the risk of long\u2010term complications.<\/jats:p>","DOI":"10.1111\/aor.12067","type":"journal-article","created":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T09:38:40Z","timestamp":1367228320000},"page":"704-711","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of Inflow Cannulation Site for Implantation of Right\u2010Sided Rotary Ventricular Assist Device"],"prefix":"10.1111","volume":"37","author":[{"given":"Shaun D.","family":"Gregory","sequence":"first","affiliation":[{"name":"Medical Device Domain, Institute of Health and Biomedical Innovation Queensland University of Technology Brisbane QLD Australia"},{"name":"Critical Care Research Group The Prince Charles Hospital Brisbane QLD Australia"},{"name":"Innovative Cardiovascular Engineering and Technology Laboratory The Prince Charles Hospital Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Pearcy","sequence":"additional","affiliation":[{"name":"Medical Device Domain, Institute of Health and Biomedical Innovation Queensland University of Technology Brisbane QLD Australia"},{"name":"Innovative Cardiovascular Engineering and Technology Laboratory The Prince Charles Hospital Brisbane QLD Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Fraser","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital Brisbane QLD Australia"},{"name":"Innovative Cardiovascular Engineering and Technology Laboratory The Prince Charles Hospital Brisbane QLD Australia"},{"name":"BiVACOR Pty Ltd. 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