{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:23:46Z","timestamp":1791307426075,"version":"4.3.1"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T00:00:00Z","timestamp":1365120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2013,10]]},"abstract":"Abstract<\/jats:title>\n \n The aim of this study is to describe the incidence of brain injury (\n BI<\/jats:styled-content>\n ) in children with end\u2010stage cardiac failure who were supported with the\n B<\/jats:styled-content>\n erlin\n H<\/jats:styled-content>\n eart\n EXCOR<\/jats:styled-content>\n ventricular assist device (\n VAD<\/jats:styled-content>\n ) as a bridge to heart transplantation. Between\n J<\/jats:styled-content>\n anuary 2002 and\n J<\/jats:styled-content>\n anuary 2012, all patients <18 years of age who underwent the implantation of the\n B<\/jats:styled-content>\n erlin\n H<\/jats:styled-content>\n eart\n EXCOR<\/jats:styled-content>\n at\n B<\/jats:styled-content>\n ambino\n G<\/jats:styled-content>\n es\u00fa\n C<\/jats:styled-content>\n hildren's\n H<\/jats:styled-content>\n ospital were included. A total of 25 patients were included in this study. Median age and weight at implantation were 22.4 months (range 3.6\u2013154.2) and 10\u2009kg (range 4.5\u201336), respectively. Diagnosis included cardiomyopathy (\n n<\/jats:italic>\n \u2009=\u200920) and congenital heart disease (\n n<\/jats:italic>\n \u2009=\u20095). Eleven patients received atrial cannulation. Nine patients underwent biventricular assist device support. Seven patients underwent extracorporeal membrane oxygenation before the implantation of the\n EXCOR VAD<\/jats:styled-content>\n . Median duration of\n VAD<\/jats:styled-content>\n support was 51 days (range 2\u2013167). Nine patients had evidence of acute\n BI<\/jats:styled-content>\n including intracranial hemorrhage (\n n<\/jats:italic>\n \u2009=\u20095) and cerebral ischemia (\n n<\/jats:italic>\n \u2009=\u20094). Freedom from\n BI<\/jats:styled-content>\n at 30, 60, and 90 days from\n VAD<\/jats:styled-content>\n implantation was 80.7, 69.9, and 43.3%, respectively. Weight <10\u2009kg at implantation was significantly associated with\n BI<\/jats:styled-content>\n .\n BI<\/jats:styled-content>\n is a frequent complication among children supported with\n EXCOR VAD<\/jats:styled-content>\n and is associated with lower weight at implantation. However, our data do not support the association between size and\n BI<\/jats:styled-content>\n . Future prospective multicenter studies are warranted to further help understand the etiology and the impact of\n BI<\/jats:styled-content>\n and to improve functional outcomes for children undergoing\n EXCOR VAD<\/jats:styled-content>\n mechanical support.\n <\/jats:p>","DOI":"10.1111\/aor.12075","type":"journal-article","created":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T06:06:45Z","timestamp":1365142005000},"page":"851-856","source":"Crossref","is-referenced-by-count":27,"title":["Neurological Complications During Pulsatile Ventricular Assistance With the\n B<\/scp>\n erlin\n H<\/scp>\n eart\n EXCOR<\/scp>\n in Children: Incidence and Risk Factors"],"prefix":"10.1111","volume":"37","author":[{"given":"Angelo","family":"Polito","sequence":"first","affiliation":[{"name":"Department of Cardiology and Cardiac Surgery and Bambino Ges\u00fa Pediatric Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Netto","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiac Surgery and Bambino Ges\u00fa Pediatric Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Soldati","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Bambino Ges\u00fa Pediatric Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Brancaccio","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiac Surgery and Bambino Ges\u00fa Pediatric Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Grutter","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiac Surgery and Bambino Ges\u00fa Pediatric Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Amodeo","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiac Surgery and Bambino Ges\u00fa Pediatric Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaccaria","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiac Surgery and Bambino Ges\u00fa Pediatric Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Morelli","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiac Surgery and Bambino Ges\u00fa Pediatric Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Cogo","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiac Surgery and Bambino Ges\u00fa Pediatric Hospital Rome 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