{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T10:45:28Z","timestamp":1756809928390},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T00:00:00Z","timestamp":1369008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sinusoidal obstruction syndrome (<jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content>) is one of the severe complications of hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>). Systemic management including respiratory and circulatory support is necessary. In addition, abdominal paracentesis is often needed for pain relief and to reduce the pressure of tense ascites. Concentrated ascites reinfusion therapy (<jats:styled-content style=\"fixed-case\">CART<\/jats:styled-content>) involves the filtration, concentration, and reinfusion of drained ascites, which contributes to reuse of autologous proteins. <jats:styled-content style=\"fixed-case\">CART<\/jats:styled-content> has been reported as supportive therapy for patients with liver cirrhosis and cancer. We retrospectively reviewed the efficacy and safety of <jats:styled-content style=\"fixed-case\">CART<\/jats:styled-content> in three patients (two with acute myelogenous leukemia and one with chronic myeloid leukemia) who developed <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> after allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>. They all had symptomatic, tense, and diuretic\u2010refractory ascites with right costal pain and marked weight gain. Two patients showed immediate improvement after <jats:styled-content style=\"fixed-case\">CART<\/jats:styled-content>. However, one patient experienced four <jats:styled-content style=\"fixed-case\">CARTs<\/jats:styled-content> with slow recovery. All patients are now alive and are being monitored as outpatients over 2 years with remission. No severe adverse event was observed related to <jats:styled-content style=\"fixed-case\">CART<\/jats:styled-content>, and 25.2\u201398.0 (median 30.2) grams of albumin was collected and reinfused. <jats:styled-content style=\"fixed-case\">CART<\/jats:styled-content> after paracentesis reduces protein loss in ascites by reinfusion of autologous protein instead of exogenous albumin preparations. Although transient fever is reported as a frequent adverse event, no events like severe bleeding or infection were observed. While its safety has not been fully established in patients with hematological disease after <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CART<\/jats:styled-content> may be a considerable supportive therapy for <jats:styled-content style=\"fixed-case\">SOS<\/jats:styled-content> with tense ascites.<\/jats:p>","DOI":"10.1111\/aor.12080","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T04:32:08Z","timestamp":1369110728000},"page":"932-936","source":"Crossref","is-referenced-by-count":7,"title":["Concentrated Ascites Reinfusion Therapy for Sinusoidal Obstructive Syndrome After Hematopoietic Stem Cell Transplantation"],"prefix":"10.1111","volume":"37","author":[{"given":"Hiroyuki","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rika","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Kanagawa Cancer Center  Yokohama Japan"},{"name":"Department of Hematology Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Hematology Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Hematology Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukako","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Hematology Yokohama City University Medical Center  Yokohama 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