{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T22:01:20Z","timestamp":1717797680258},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T00:00:00Z","timestamp":1372896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Disruption of microcirculation in various tissues as a result of deformed blood rheology due to ventricular assist device (<jats:styled-content style=\"fixed-case\">VAD<\/jats:styled-content>) implantation causes novel arteriovenous malformations. Capillary disturbances and related vascular leakage in the retina and choroidea may also be seen in patients supported by <jats:styled-content style=\"fixed-case\">VADs<\/jats:styled-content>. We aimed to evaluate retinal vasculature deteriorations after <jats:styled-content style=\"fixed-case\">VAD<\/jats:styled-content> implantation. The charts of 17 patients who underwent <jats:styled-content style=\"fixed-case\">VAD<\/jats:styled-content> implantation surgery for the treatment of end\u2010stage heart failure were retrospectively reviewed. Eight cases (47.1%) underwent pulsatile pump implantation (<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>erlin <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>eart <jats:styled-content style=\"fixed-case\">EXCOR<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>erlin <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>eart <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ediprodukt <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>mb<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>, Berlin, <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ermany); however, nine cases (52.9%) had continuous\u2010flow pump using centrifugal design (<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>eart<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>are, <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>eart<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>are <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nc., <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>iramar, <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>). Study participants were selected among the patients who had survived with a <jats:styled-content style=\"fixed-case\">VAD<\/jats:styled-content> for at least 6 months, and results of detailed ophthalmologic examinations including optic coherence tomography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) and fundus fluorescein angiography (<jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content>) were documented. All of the 17 patients were male, with a mean age of 48.5\u2009\u00b1\u200914.8 years (15\u201367 years). Detailed ophthalmologic examinations including the evaluation of retinal vascular deteriorations via <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> were performed at a mean of 11.8\u2009\u00b1\u20093.7 months of follow\u2010up (6\u201318 months). Mean best\u2010corrected visual acuity and intraocular pressure were found as log<jats:styled-content style=\"fixed-case\">MAR<\/jats:styled-content> 0.02\u2009\u00b1\u20090.08 and 14.6\u2009\u00b1\u20091.9\u2009mm\u2009Hg, respectively in the study population. Dilated fundoscopy revealed severe focal arteriolar narrowing in two patients (11.8%), and arteriovenous crossing changes in four patients (23.5%); however, no pathological alteration was present in macular <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> scans. In patients with continuous\u2010flow blood pumps, mean arm\u2010retina circulation time (<jats:styled-content style=\"fixed-case\">ARCT<\/jats:styled-content>) and arteriovenous transit time (<jats:styled-content style=\"fixed-case\">AVTT<\/jats:styled-content>) were found to be 16.8\u2009\u00b1\u20093.0 and 12.4\u2009\u00b1\u20096.2\u2009s, respectively; whereas those with pulsatile\u2010flow blood pumps were found to be 17.4\u2009\u00b1\u20093.6 and 14.0\u2009\u00b1\u20092.1\u2009s in patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.526 and <jats:italic>P<\/jats:italic>\u2009=\u20090.356, respectively). <jats:styled-content style=\"fixed-case\">FA<\/jats:styled-content> also revealed a tendency for increased frequency of dye leakage from the optic disc in our study population. Except for remarkable delays in both <jats:styled-content style=\"fixed-case\">ARCT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AVTT<\/jats:styled-content> as well as a tendency for increased frequency of dye leakage from the optic disc, ophthalmologic evaluations revealed no other significant pathology or vascular deterioration in the retina that could be attributed to artificial heart systems.<\/jats:p>","DOI":"10.1111\/aor.12123","type":"journal-article","created":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T13:52:44Z","timestamp":1372945964000},"page":"816-820","source":"Crossref","is-referenced-by-count":2,"title":["Fundus Fluorescein Angiographic Findings in Patients Who Underwent Ventricular Assist Device Implantation"],"prefix":"10.1111","volume":"37","author":[{"given":"Taylan","family":"Ozturk","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Dokuz Eylul University School of Medicine  Izmir 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