{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:05:25Z","timestamp":1790251525569,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T00:00:00Z","timestamp":1374710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Abstract<\/jats:title>This study aims to investigate differences in hemodynamic conditions in the thoracic aorta for pulsatile and continuous\u2010flow left ventricular assist devices (LVAD<\/jats:styled-content>s) using computational fluid dynamics (CFD<\/jats:styled-content>). Patient\u2010specific models were reconstructed from three patients with continuous\u2010flow LVAD<\/jats:styled-content> (H<\/jats:styled-content>eartM<\/jats:styled-content>ate II<\/jats:styled-content>, T<\/jats:styled-content>horatec C<\/jats:styled-content>orporation) and three patients with biventricular assist devices (E<\/jats:styled-content>xcor, B<\/jats:styled-content>erlin H<\/jats:styled-content>eart) where only the aortic part was included in the simulations. CFD<\/jats:styled-content> simulations were performed with constant inflow for the continuous\u2010flow LVADs<\/jats:styled-content> and time\u2010varying inflow for the pulsatile devices. Differences in flow patterns, wall shear stress (WSS<\/jats:styled-content>), and dynamic pressure in the ascending aorta were compared for both cases. Retrograde flow patterns were observed in all cases proximal to the location of the outflow cannula anastomosis site. On average, dynamic pressures derived from the retrograde flow velocities were higher in the continuous\u2010flow group with large variations dependent on the angle of the cannula anastomosis relative to the ascending aorta (continuous group: 0.14\u2009\u00b1\u20090.2\u2009mm\u2009Hg<\/jats:styled-content>, pulsatile group: 0.013\u2009\u00b1\u20090.008\u2009mm\u2009Hg<\/jats:styled-content>). Elevated WSS<\/jats:styled-content> contralaterally to the anastomosis site was observed in three of the six models with higher values for the continuous cases. Lower WSS<\/jats:styled-content> and reduced pressure in the ascending aorta, both favorable hemodynamic conditions, were found in pulsatile versus continuous\u2010flow LVADs<\/jats:styled-content> by means of CFD<\/jats:styled-content>. These findings indicate, along with clinical observations reported by others, the superior performance of pulsatile LVADs<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/aor.12132","type":"journal-article","created":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T09:32:39Z","timestamp":1374831159000},"page":"142-148","source":"Crossref","is-referenced-by-count":33,"title":["Comparison of Hemodynamics in the Ascending Aorta Between Pulsatile and Continuous Flow Left Ventricular Assist Devices Using Computational Fluid Dynamics Based on Computed Tomography Images"],"prefix":"10.1111","volume":"38","author":[{"given":"Christof","family":"Karmonik","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The Methodist Hospital Houston TX USA"},{"name":"Methodist DeBakey Heart & Vascular Center The Methodist Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasan","family":"Partovi","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospitals Case Medical Center Case Western Reserve University Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastian","family":"Schmack","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery University Hospital of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Weymann","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery University Hospital of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Loebe","sequence":"additional","affiliation":[{"name":"Methodist DeBakey Heart & Vascular Center The Methodist Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George 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