{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:51:12Z","timestamp":1760122272780},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Abstract:\u2002<\/jats:title>Aortic insufficiency (AI<\/jats:styled-content>) is usually repaired prior to rotary blood pump (RBP<\/jats:styled-content>) implantation but can develop during support due, in part, to the sustained RBP<\/jats:styled-content>\u2010induced high pressure gradient across the aortic valve. Repair of the aortic valve before or during RBP<\/jats:styled-content> support predisposes these critically ill patients to even higher risks. This study used an in vitro mock circulation loop to identify the severity of AI<\/jats:styled-content> and\/or left heart failure (LHF<\/jats:styled-content>) that might benefit from valve repair while investigating RBP<\/jats:styled-content> operating strategies to reduce the hemodynamic influence of AI<\/jats:styled-content>. Reproduction of AI<\/jats:styled-content> with RBP<\/jats:styled-content>\u2010supported LHF<\/jats:styled-content> reduced device efficiency, particularly in the more severe cases of AI<\/jats:styled-content> and LHF<\/jats:styled-content>. The requirement for repair or closure of the aortic valve was demonstrated in all conditions other than those with only mild AI<\/jats:styled-content>. When a sinusoidal RBP<\/jats:styled-content> speed pulse was induced, small changes in systemic flow rate and regurgitant volume were observed with all degrees of AI<\/jats:styled-content>. Variation of the pulse phase delay only resulted in minor changes to systemic flow rate, with a maximum difference of 0.17\u2009L<\/jats:styled-content>\/min. Although the clinical implications of these small changes may be insignificant, changes in systemic flow rate and transvalvular pressure were shown when the sinusoidal RBP<\/jats:styled-content> speed pulse was applied with no AI<\/jats:styled-content>. In these cases, transvalvular pressure was reduced by up to 8% through sinusoidal copulsation of the RBP<\/jats:styled-content>, which may prevent or delay the onset of AI<\/jats:styled-content>. This in vitro study suggests that surgical intervention is required with moderate or worse AI<\/jats:styled-content> and that RBP<\/jats:styled-content> operating strategies should be further explored to delay the onset and reduce the harmful effects of AI<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/aor.12143","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T05:50:49Z","timestamp":1375336249000},"page":"802-809","source":"Crossref","is-referenced-by-count":14,"title":["In Vitro Evaluation of Aortic Insufficiency With a Rotary Left Ventricular Assist Device"],"prefix":"10.1111","volume":"37","author":[{"given":"Shaun D.","family":"Gregory","sequence":"first","affiliation":[{"name":"School of Medicine University of Queensland Brisbane Queensland Australia"},{"name":"Innovative Cardiovascular Engineering and Technology Laboratory The Prince Charles Hospital Brisbane Queensland Australia"},{"name":"Critical Care Research Group The Prince Charles Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C.","family":"Stevens","sequence":"additional","affiliation":[{"name":"School of Information Technology and Electrical Engineering University of Queensland Brisbane Queensland Australia"},{"name":"Innovative Cardiovascular Engineering and Technology Laboratory The Prince Charles Hospital Brisbane Queensland Australia"},{"name":"Critical Care Research Group The Prince Charles Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Wu","sequence":"additional","affiliation":[{"name":"Innovative Cardiovascular Engineering and Technology Laboratory The Prince Charles Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Fraser","sequence":"additional","affiliation":[{"name":"School of Medicine University of Queensland Brisbane Queensland Australia"},{"name":"Innovative Cardiovascular Engineering and Technology Laboratory The Prince Charles Hospital Brisbane Queensland Australia"},{"name":"Critical Care Research Group The Prince Charles Hospital Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Timms","sequence":"additional","affiliation":[{"name":"School of Medicine University of Queensland Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-011-0348-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909938"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.302095734"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.109.917765"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-1106"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.10.009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.05.029"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.04.115"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.11.007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e318271bc49"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.08.072"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.844274"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2010.05.040"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e31816a309b"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.01.011"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3181e321da"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs299"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1057\/jos.2009.15"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2010.01088.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.2002.06870.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","unstructured":"GregorySD StevensM TimmsD PearcyM.Replication of the Frank\u2010Starling response in a mock circulation loop. 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