{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:23:42Z","timestamp":1792607022798,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T00:00:00Z","timestamp":1378857600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2013,9]]},"abstract":"Abstract<\/jats:title>Pulmonary hypertension (PH<\/jats:styled-content>) is considered as a risk factor for morbidity and mortality in patients undergoing heart transplantation. Recently, left ventricular assist device (LVAD<\/jats:styled-content>) implantation has been increasingly used in reducing pulmonary artery pressure (PAP<\/jats:styled-content>) in patients with PH<\/jats:styled-content> unresponsive to medical therapy. Herein, we aimed to compare the efficacy of continuous\u2010flow and pulsatile\u2010flow blood pumps on the improvement of PH<\/jats:styled-content> in mechanical circulatory support patients. Twenty\u2010seven patients with end\u2010stage heart failure who underwent LVAD<\/jats:styled-content> implantation surgery were enrolled. Fifteen of them (55.6%) had continuous\u2010flow pump (HeartWare Ventricular Assist System, HeartWare, Inc., Miramar, FL, USA), and 12 of them (44.4%) had pulsatile pump (Berlin Heart EXCOR ventricular assist device, Berlin Heart AG, Berlin, Germany). The efficacy of LVAD<\/jats:styled-content>s on the improvement of PH<\/jats:styled-content> was compared between continuous\u2010flow and pulsatile pumps by the evaluation of systolic PAP<\/jats:styled-content>, tricuspid annular plane systolic excursion (TAPSE<\/jats:styled-content>), right ventricular systolic motion (RVSM<\/jats:styled-content>), right ventricular ejection fraction (RVEF<\/jats:styled-content>), and grade of tricuspid insufficiency (TI<\/jats:styled-content>) for each of the study participants. All of the 15 patients who underwent continuous\u2010flow blood pump implantation surgery (Group 1) were male with a mean age of 46.9\u2009\u00b1\u200911.7 years, and in pulsatile\u2010flow blood pump implanted participants (Group 2), the mean age was 40.6\u2009\u00b1\u200916.8 years, all of whom were also male (P<\/jats:italic>\u2009=\u20090.259). Mean follow\u2010up was 313.7\u2009\u00b1\u2009241.3 days in Group 1 and 448.7\u2009\u00b1\u2009120.7 days in Group 2 (P<\/jats:italic>\u2009=\u20090.139). In Group 1, mean preoperative and postoperative systolic PAP were measured as 51.7\u2009\u00b1\u200912.2\u2009mm\u2009Hg and 22.2\u2009\u00b1\u20093.4\u2009mm\u2009Hg, respectively, while those in Group 2 were 54.5\u2009\u00b1\u20097.5\u2009mm\u2009Hg and 33.9\u2009\u00b1\u20096.4\u2009mm\u2009Hg, respectively. A significantly greater decrease in systolic PAP<\/jats:styled-content> was noticed in patients with continuous\u2010flow blood pumps (P<\/jats:italic>\u2009=\u20090.023); however, no statistically significant difference was found when we considered the change in TAPSE<\/jats:styled-content> between study groups (P<\/jats:italic>\u2009=\u20090.112). A statistical significance in the alteration of RVEF<\/jats:styled-content>, RVSM<\/jats:styled-content>, and the grade of TI<\/jats:styled-content> during study visits was not found between the study groups (P<\/jats:italic>\u2009=\u20090.472, P<\/jats:italic>\u2009=\u20090.887, and P<\/jats:italic>\u2009=\u20090.237, respectively). Although the two studied types of LVAD<\/jats:styled-content>s were found to be effective in reducing PAP<\/jats:styled-content> in heart transplantation candidates with PH<\/jats:styled-content>, lesser postoperative systolic PAP<\/jats:styled-content> values were achieved in patients who underwent continuous\u2010flow pump implantation surgery.<\/jats:p>","DOI":"10.1111\/aor.12164","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T11:39:02Z","timestamp":1378899542000},"page":"763-767","source":"Crossref","is-referenced-by-count":18,"title":["Comparison of Continuous\u2010Flow and Pulsatile\u2010Flow Blood Pumps on Reducing Pulmonary Artery Pressure in Patients With Fixed Pulmonary Hypertension"],"prefix":"10.1111","volume":"37","author":[{"given":"Pelin","family":"Ozturk","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Ege University Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysen Yaprak","family":"Engin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Ege University Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanem","family":"Nalbantgil","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ege University Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrah","family":"Oguz","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Ege University Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Ayik","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Ege University Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cagatay","family":"Engin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Ege University Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahir","family":"Yagdi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Ege University Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"Erkul","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Ege University Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Balcioglu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Ege University Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Ozbaran","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Ege University Hospital Izmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00139009"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90050-W"},{"key":"e_1_2_6_4_1","first-page":"526","article-title":"Influence of preoperative transpulmonary gradient on late mortality after orthotopic heart transplantation","volume":"9","author":"Erickson KW","year":"1990","journal-title":"J Heart 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of fixed pulmonary hypertension in left ventricular assist device support recipients","volume":"40","author":"Mikus E","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.08.005"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.04.011"},{"key":"e_1_2_6_17_1","first-page":"848","article-title":"Sildenafil vs. sodium before nitroprusside for the pulmonary hypertension reversibility test before cardiac transplantation","volume":"99","author":"Freitas AF","year":"2012","journal-title":"Arq Bras Cardiol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2005.08.018"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12164","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T06:35:36Z","timestamp":1696487736000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/aor.12164"],"URL":"https:\/\/doi.org\/10.1111\/aor.12164","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}