{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:53:40Z","timestamp":1789012420448,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":712,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1111\/aor.12168","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T14:01:55Z","timestamp":1381240915000},"page":"342-346","source":"Crossref","is-referenced-by-count":26,"title":["Primary Anticoagulation With Bivalirudin for Patients With Implantable Ventricular Assist Devices"],"prefix":"10.1111","volume":"38","author":[{"given":"Marina","family":"Pieri","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Intensive Care; San Raffaele Scientific Institute; Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Agracheva","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care; San Raffaele Scientific Institute; Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambra Licia","family":"Di Prima","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care; San Raffaele Scientific Institute; Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodora","family":"Nisi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery; San Raffaele Scientific Institute; Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"De Bonis","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery; San Raffaele Scientific Institute; Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Isella","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care; San Raffaele Scientific Institute; Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Zangrillo","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care; San Raffaele Scientific Institute; Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Pappalardo","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care; San Raffaele Scientific Institute; Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,19]]},"reference":[{"key":"10.1111\/aor.12168-BIB0001|aor12168-cit-0001","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.athoracsur.2006.05.077","article-title":"Impact of heparin-induced thrombocytopenia on outcome in patients with ventricular assist device support: single-institution experience in 358 consecutive patients","volume":"83","author":"Koster","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1111\/aor.12168-BIB0002|aor12168-cit-0002","first-page":"330","article-title":"Argatroban anticoagulation for heparin induced thrombocytopenia in patients with ventricular assist devices","volume":"78","author":"Pappalardo","year":"2012","journal-title":"Minerva Anestesiol"},{"key":"10.1111\/aor.12168-BIB0003|aor12168-cit-0003","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1160\/TH07-10-0644","article-title":"Bivalirudin","volume":"99","author":"Warkentin","year":"2008","journal-title":"Thromb Haemost"},{"key":"10.1111\/aor.12168-BIB0004|aor12168-cit-0004","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1055\/s-0038-1648515","article-title":"Heparin binding to plasma proteins, an important mechanism for heparin resistance","volume":"67","author":"Young","year":"1992","journal-title":"Thromb Haemost"},{"key":"10.1111\/aor.12168-BIB0005|aor12168-cit-0005","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0167-4889(85)90177-6","article-title":"Binding and endocytosis of heparin by human endothelial cells in culture","volume":"845","author":"Barzu","year":"1985","journal-title":"Biochim Biophys Acta"},{"key":"10.1111\/aor.12168-BIB0006|aor12168-cit-0006","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1177\/026765919901400606","article-title":"Predictors for heparin resistance in patients undergoing coronary artery bypass grafting","volume":"14","author":"Ranucci","year":"1999","journal-title":"Perfusion"},{"key":"10.1111\/aor.12168-BIB0007|aor12168-cit-0007","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.amjcard.2007.02.106","article-title":"Comparison of platelet function and morphology in patients undergoing percutaneous coronary intervention receiving bivalirudin versus unfractionated heparin versus clopidogrel pretreatment and bivalirudin","volume":"100","author":"Anand","year":"2007","journal-title":"Am J Cardiol"},{"key":"10.1111\/aor.12168-BIB0008|aor12168-cit-0008","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1055\/s-0037-1616529","article-title":"Human thrombi contain an abundance of active thrombin","volume":"86","author":"Mutch","year":"2001","journal-title":"Thromb Haemost"},{"key":"10.1111\/aor.12168-BIB0009|aor12168-cit-0009","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1172\/JCI114723","article-title":"Clot bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors","volume":"86","author":"Weitz","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1111\/aor.12168-BIB0010|aor12168-cit-0010","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.healun.2010.02.003","article-title":"Post-operative heparin may not be required for transitioning patients with a HeartMate II left ventricular assist system to long-term warfarin therapy","volume":"29","author":"Slaughter","year":"2010","journal-title":"J Heart Lung Transplant"},{"key":"10.1111\/aor.12168-BIB0011|aor12168-cit-0011","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s12630-010-9423-0","article-title":"Bivalirudin utilization in cardiac surgery: shifting anticoagulation from indirect to direct thrombin inhibition","volume":"58","author":"Anand","year":"2011","journal-title":"Can J Anaesth"},{"key":"10.1111\/aor.12168-BIB0012|aor12168-cit-0012","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1056\/NEJMoa012175","article-title":"Long-term use of a left ventricular assist device for end-stage heart failure","volume":"345","author":"Rose","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1111\/aor.12168-BIB0013|aor12168-cit-0013","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1067\/mtc.2001.118274","article-title":"Multicenter clinical evaluation of the HeartMate vented electric left ventricular assist system in patients awaiting heart transplantation","volume":"122","author":"Frazier","year":"2001","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1111\/aor.12168-BIB0014|aor12168-cit-0014","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.jacc.2010.10.062","article-title":"Results of the post-U.S. Food and Drug administration-approval study with a continuous flow left ventricular assist device as a bridge to heart transplantation","volume":"57","author":"Starling","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1111\/aor.12168-BIB0015|aor12168-cit-0015","first-page":"S11","article-title":"Reversing anticoagulants both old and new","volume":"49","author":"Warkentin","year":"2002","journal-title":"Can J Anaesth"},{"key":"10.1111\/aor.12168-BIB0016|aor12168-cit-0016","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1053\/j.jvca.2012.07.019","article-title":"Bivalirudin versus heparin as anticoagulant during extracorporeal membrane oxygenation: a case-control study","volume":"27","author":"Pieri","year":"2013","journal-title":"J Cardiothorac Vasc Anesth"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12168","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T18:13:00Z","timestamp":1625422380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12168"}},"subtitle":["Thoughts and Progress"],"short-title":[],"issued":{"date-parts":[[2013,9,19]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"URL":"https:\/\/doi.org\/10.1111\/aor.12168","relation":{},"ISSN":["0160-564X"],"issn-type":[{"value":"0160-564X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9,19]]}}}