{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T20:02:54Z","timestamp":1760472174861},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T00:00:00Z","timestamp":1381449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Reports on third\u2010generation centrifugal intrapericardial pumps (<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>eart<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>are <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nternational, <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nc., <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ramingham, <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>) have shown better survival results than the previous\u2010generation devices. However, outcomes depending on the preoperative level of stability can substantially differ, resulting in a limited analysis of potentialities and drawbacks of a given device. In the present study we sought to compare in our single\u2010center experience the survival results of this third\u2010generation device with previous left ventricular systems taking into account the different preoperative Interagency Registry for Mechanically Assisted Circulatory Support (<jats:styled-content style=\"fixed-case\">INTERMACS<\/jats:styled-content>) levels. Between February 1993 and March 2012, 287 patients underwent assist device implantation in our university hospital (<jats:styled-content style=\"fixed-case\">INTERMACS<\/jats:styled-content> Level 1\u20102\u2009=\u2009158 patients; <jats:styled-content style=\"fixed-case\">INTERMACS<\/jats:styled-content> Level 3\u20104\u20105\u2009=\u2009129 patients). Assist devices implanted were: Group A (<jats:styled-content style=\"fixed-case\">HVAD<\/jats:styled-content> HeartWare, <jats:italic>n<\/jats:italic>\u2009=\u200952), group B (previous continuous\u2010flow ventricular assist device [<jats:styled-content style=\"fixed-case\">VAD<\/jats:styled-content>], <jats:styled-content style=\"fixed-case\">InCor<\/jats:styled-content> [Berlin Heart, Berlin, Germany],<jats:italic> n<\/jats:italic>\u2009=\u200937; <jats:styled-content style=\"fixed-case\">VentrAssist<\/jats:styled-content> [VentraCor, Inc., Chatswood, NSW, Australia], <jats:italic>n<\/jats:italic>\u2009=\u20097; <jats:styled-content style=\"fixed-case\">DeBakey<\/jats:styled-content> [MicroMed Cardiovascular, Inc., Houston, TX, USA], <jats:italic>n<\/jats:italic>\u2009=\u200932), and group C (pulsatile systems, <jats:italic>n<\/jats:italic>\u2009=\u2009159). After cumulative support duration of 54\u2009436 days and a mean follow\u2010up of 6.21\u2009\u00b1\u20097.46 months (range 0\u201345.21 months), log\u2010rank analysis revealed a survival for group A of 82.0%, 70.4%, and 70.4%; for group B of 84.0%, 48.2%, 33.7%; and for group C of 71.6%, 46.1%, 33.8%, at 1, 12, and 24 months respectively, with a significantly (<jats:italic>P<\/jats:italic>\u2009=\u20090.013) better outcome for group A. When stratifying the survival on the basis of <jats:styled-content style=\"fixed-case\">INTERMACS<\/jats:styled-content> level, no significant survival improvement was observed among all patients who underwent <jats:styled-content style=\"fixed-case\">VAD<\/jats:styled-content> implantation in <jats:styled-content style=\"fixed-case\">INTERMACS<\/jats:styled-content> 1\u20102 (<jats:italic>P<\/jats:italic>\u2009=\u20090.47). However, among patients who underwent elective <jats:styled-content style=\"fixed-case\">VAD<\/jats:styled-content> implantation (<jats:styled-content style=\"fixed-case\">INTERMACS<\/jats:styled-content> 3\u20104\u20105), group A had a significantly better outcome (<jats:italic>P<\/jats:italic>\u2009=\u20090.005) compared with the other <jats:styled-content style=\"fixed-case\">INTERMACS<\/jats:styled-content>\u2010matched groups (B,C) with a survival rate of 88.8% in group A versus 34.2% in group B and 45.6% in group C at 24 months, respectively. Elective <jats:styled-content style=\"fixed-case\">HVAD<\/jats:styled-content> system implantation shows improved survival benefit over the other <jats:styled-content style=\"fixed-case\">INTERMACS<\/jats:styled-content>\u2010matched devices. Moreover, preoperative unstable hemodynamics resulted in a poor prognosis independently from the pump generation.<\/jats:p>","DOI":"10.1111\/aor.12188","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T11:05:54Z","timestamp":1381748754000},"page":"383-390","source":"Crossref","is-referenced-by-count":8,"title":["Survival Results After Implantation of Intrapericardial Third\u2010Generation Centrifugal Assist Device: An <scp>INTERMACS<\/scp>\u2010Matched Comparison Analysis"],"prefix":"10.1111","volume":"38","author":[{"given":"Angelo M.","family":"Dell'Aquila","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery University of Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan R.B.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University of Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Stypmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology University of Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Ellger","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine University of Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bassam","family":"Redwan","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University of Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Schlarb","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University of Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University of Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen R.","family":"Sindermann","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University of Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012175"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2011.07.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.01.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.12.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.05.016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.10.040"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.011502"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.09.055"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.10.016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2009.04.033"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.02.006"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12188","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T23:16:35Z","timestamp":1696461395000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,11]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/aor.12188"],"URL":"https:\/\/doi.org\/10.1111\/aor.12188","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,11]]}}}