{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:08:26Z","timestamp":1760249306791},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T00:00:00Z","timestamp":1381449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Abstract<\/jats:title>Early and accurate noninvasive means of identifying right ventricular (RV<\/jats:styled-content>) dysfunction in children with tetralogy of Fallot (TOF<\/jats:styled-content>) are needed. RV<\/jats:styled-content> function was examined using tissue D<\/jats:styled-content>oppler imaging (TDI<\/jats:styled-content>), strain rate (SR<\/jats:styled-content>), and strain analysis (SA<\/jats:styled-content>) in children before (N<\/jats:italic>\u2009=\u200937) and after (6\u201312 months; N<\/jats:italic>\u2009=\u200932) TOF<\/jats:styled-content> repair, and in a control group of children (N<\/jats:italic>\u2009=\u200937). Plasma concentrations of N<\/jats:styled-content>\u2010terminal pro\u2010brain natriuretic peptide (NT<\/jats:styled-content>\u2010proBNP<\/jats:styled-content>) and matrix metalloproteinase 9 (MMP<\/jats:styled-content>\u20109) were measured. TDI<\/jats:styled-content>, SR<\/jats:styled-content>, and SA<\/jats:styled-content> revealed that RV<\/jats:styled-content> systolic and diastolic function indices were lower preoperatively in the TOF<\/jats:styled-content> group compared with the control group, and did not improve after TOF<\/jats:styled-content> repair. Plasma NT<\/jats:styled-content>\u2010proBNP<\/jats:styled-content> concentrations were significantly higher in the TOF<\/jats:styled-content> group pre\u2010 and postoperatively compared with the control group. In the preoperative TOF<\/jats:styled-content> group, NT<\/jats:styled-content>\u2010proBNP<\/jats:styled-content> concentration was significantly correlated with peak systolic SR<\/jats:styled-content> and systolic strain in the mid segments of RV<\/jats:styled-content> free wall. Plasma MMP<\/jats:styled-content>\u20109 concentrations were significantly increased in the preoperative TOF<\/jats:styled-content> group compared with the control group, and significantly correlated with plasma NT<\/jats:styled-content>\u2010proBNP<\/jats:styled-content> and logNT<\/jats:styled-content>\u2010proBNP<\/jats:styled-content> concentrations. RV<\/jats:styled-content> function correlated with plasma NT<\/jats:styled-content>\u2010proBNP<\/jats:styled-content> concentrations in children with TOF<\/jats:styled-content>. Assessment of this noninvasive measure may help identify RV<\/jats:styled-content> dysfunction in patients with TOF<\/jats:styled-content> before they become clinically symptomatic.<\/jats:p>","DOI":"10.1111\/aor.12189","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T11:53:04Z","timestamp":1381751584000},"page":"41-47","source":"Crossref","is-referenced-by-count":9,"title":["Noninvasive Perioperative Evaluation of Right Ventricular Function in Children With Tetralogy of Fallot"],"prefix":"10.1111","volume":"38","author":[{"given":"Jing\u2010Jing","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Ultrasonography The Children's Hospital of Zhejiang University and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery The Children's Hospital of Zhejiang University and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi\u2010Wang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery The Children's Hospital of Zhejiang University and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010zhong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pathology The Children's Hospital of Zhejiang University and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography The Children's Hospital of Zhejiang University and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo\u2010ping","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography The Children's Hospital of Zhejiang University and Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases Hangzhou 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