{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:54:27Z","timestamp":1778630067184,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Abstract<\/jats:title>Pediatric patients supported on ventricular assist devices (VAD<\/jats:styled-content>s) require systemic anticoagulation and are at risk for intracranial hemorrhage (ICH<\/jats:styled-content>). Little is known about the incidence or outcomes of pediatric patients with ICH<\/jats:styled-content> while supported on a VAD<\/jats:styled-content>. A retrospective chart review of all patients receiving VAD<\/jats:styled-content> support was completed. Patients diagnosed with ICH<\/jats:styled-content> while supported on a VAD<\/jats:styled-content> were identified. Significant factors prior to diagnosis of ICH<\/jats:styled-content>, medical\/surgical treatment of ICH<\/jats:styled-content>, and patient outcomes were assessed. Five of 30 (17%) patients supported on a VAD<\/jats:styled-content> from January 2000 to November 2012 were diagnosed with an ICH<\/jats:styled-content>. Four patients had an identified cerebral thromboembolic injury prior to the ICH<\/jats:styled-content>. Four patients required interruption in their anticoagulation regimen due to other bleeding concerns prior to ICH<\/jats:styled-content>. Neurosurgical intervention consisted of evacuation of hemorrhage in one, whereas two others required management of hydrocephalus with external ventricular drainage. Three of the five patients died on VAD<\/jats:styled-content> support. Two deaths were directly related to ICH<\/jats:styled-content>, whereas the third was unrelated. Two patients were successfully transplanted; one remains with a significant neurological impairment, and the other has recovered with minimal residual impairment following neurosurgical evacuation of a large subdural hematoma. ICH<\/jats:styled-content> is a devastating complication of VAD<\/jats:styled-content> support. Prior ischemic infarcts and interruptions to anticoagulation may put a patient at risk for ICH<\/jats:styled-content>. Prompt neurosurgical evaluation\/intervention can result in positive outcomes.<\/jats:p>","DOI":"10.1111\/aor.12209","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T10:09:02Z","timestamp":1385028542000},"page":"73-78","source":"Crossref","is-referenced-by-count":10,"title":["Incidence and Outcome of Pediatric Patients With Intracranial Hemorrhage While Supported on Ventricular Assist Devices"],"prefix":"10.1111","volume":"38","author":[{"given":"Robert A.","family":"Niebler","sequence":"first","affiliation":[{"name":"Department of Pediatrics Section of Critical Care The Medical College of Wisconsin Milwaukee WI USA"},{"name":"Herma Heart Center Children's Hospital of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean M.","family":"Lew","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery The Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Zangwill","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Cardiology The Medical College of Wisconsin Milwaukee WI USA"},{"name":"Herma Heart Center Children's Hospital of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald K.","family":"Woods","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery The Medical College of Wisconsin Milwaukee WI USA"},{"name":"Herma Heart Center Children's Hospital of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery The Medical College of Wisconsin Milwaukee WI USA"},{"name":"Herma Heart Center Children's Hospital of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S.","family":"Tweddell","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery The Medical College of Wisconsin Milwaukee WI USA"},{"name":"Herma Heart Center Children's Hospital of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy S.","family":"Ghanayem","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Section of Critical Care The Medical College of Wisconsin Milwaukee WI USA"},{"name":"Herma Heart Center Children's Hospital of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.03.065"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014164"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.04.107"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3181c40048"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0b013e3181eee55e"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/adpa.2001.23019"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(01)00268-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mat.0000169141.01817.e0"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2009.00939.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.7.PEDS12161"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.05.026"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T12:41:12Z","timestamp":1695732072000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,21]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/aor.12209"],"URL":"https:\/\/doi.org\/10.1111\/aor.12209","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,21]]}}}