{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:05:15Z","timestamp":1759482315445},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been speculated that testosterone stimulates erythropoiesis. We hypothesized that hemoglobin levels in hemodialysis (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>) patients are associated with serum testosterone concentrations. Testosterone, hemoglobin, and other biochemical parameters were measured in a representative sample of 98 chronic <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients (50 male, 48 female; age 30\u201390 years, mean 65\u2009\u00b1\u200913.9 years). We investigated relations among serum testosterone concentration, hemoglobin, ferritin, albumin, body mass index, lean body mass, total cholesterol, low\u2010density lipoprotein and high\u2010density lipoprotein cholesterol, triglycerides, high\u2010sensitivity C\u2010reactive protein (<jats:styled-content style=\"fixed-case\">hsCRP<\/jats:styled-content>), calcium (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>a), <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>, intact parathyroid hormone, N\u2010terminal pro\u2010brain natriuretic peptide, <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>arnofsky performance status, and blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) before and after <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>. A statistically significant positive correlation between testosterone and hemoglobin was found in all patients (<jats:italic>r<\/jats:italic>\u2009=\u20090.25, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), men (<jats:italic>r<\/jats:italic>\u2009=\u20090.34, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.02), but not in women (<jats:italic>r<\/jats:italic>\u2009=\u20090.27, <jats:italic>P<\/jats:italic>\u2009=\u20090.07). Multiple regression analysis for all patients has shown statistically significant association between hemoglobin and testosterone (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), <jats:styled-content style=\"fixed-case\">hsCRP<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.005), lean body mass (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), post\u2010<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> systolic (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.04), and diastolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.005). Multiple regression analysis in men has shown an association between hemoglobin and testosterone (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.04) and post\u2010<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> diastolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.04) and in women association between hemoglobin and testosterone (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.04), <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>a (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.03), and post\u2010<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> diastolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.03). We found an association between serum testosterone concentration and hemoglobin in male and female <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/aor.12218","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T10:09:11Z","timestamp":1385028551000},"page":"598-603","source":"Crossref","is-referenced-by-count":8,"title":["Testosterone and Hemoglobin in Hemodialysis Male and Female Patients"],"prefix":"10.1111","volume":"38","author":[{"given":"Robert","family":"Ekart","sequence":"first","affiliation":[{"name":"Department of Dialysis Clinic for Internal Medicine University Medical Centre Maribor  Maribor Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Taskovska","sequence":"additional","affiliation":[{"name":"Medical Faculty University of Maribor  Maribor Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Hojs","sequence":"additional","affiliation":[{"name":"Department of Nephrology Clinic for Internal Medicine University Medical Centre Maribor  Maribor Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastjan","family":"Bevc","sequence":"additional","affiliation":[{"name":"Department of Nephrology Clinic for Internal Medicine University Medical Centre Maribor  Maribor Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radovan","family":"Hojs","sequence":"additional","affiliation":[{"name":"Department of Nephrology Clinic for Internal Medicine University Medical Centre Maribor  Maribor Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197208242870804"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000083891"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1750745"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0864"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-149-38767"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr288"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.13.1380"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2007.01.002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0637"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03357.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5768.212"},{"key":"e_1_2_7_13_1","first-page":"279","article-title":"KDIGO clinical practice guideline for anemia in chronic kidney disease","volume":"2","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Anemia Work Group","year":"2012","journal-title":"Kidney Int Suppl"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs383"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.1.498"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008060664"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq397"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12218","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:31:39Z","timestamp":1696465899000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,21]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/aor.12218"],"URL":"https:\/\/doi.org\/10.1111\/aor.12218","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,21]]}}}