{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:25:08Z","timestamp":1785209108932,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T00:00:00Z","timestamp":1389052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent advances in medical and device therapies in heart failure have improved the survival of patients with heart failure. However, due to the limited availability of suitable heart donors, left ventricular assist devices (<jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content>s) have become an important tool as a bridge\u2010to\u2010heart transplantation for patients with refractory heart failure in <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ingapore. We report our experience with the <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>eart<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ate <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HMII<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content> (Thoratec Corporation, Pleasanton, CA, USA) as a bridge\u2010to\u2010heart transplant in our center from 2009 to 2012. This was a retrospective review of 23 consecutive patients who underwent <jats:styled-content style=\"fixed-case\">HMII LVAD<\/jats:styled-content> implantation in our center between <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ay 2009 and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2012. All patients were classified as <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nteragency <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>egistry for <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>echanically <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssisted <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>irculatory <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>upport (<jats:styled-content style=\"fixed-case\">INTERMACS<\/jats:styled-content>) levels 1 to 3 and underwent <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content> implantation as a bridge\u2010to\u2010heart transplant. There were 17 male and 6 female patients. The mean age was 43.6 years old (range 14 to 64). The etiologies of heart failure included ischemic heart disease [8], idiopathic dilated cardiomyopathy [11], viral myocarditis [2], and chemotherapy\u2010induced cardiomyopathy [2]. Nine patients were <jats:styled-content style=\"fixed-case\">INTERMACS<\/jats:styled-content> level 1, 12 patients level 2, and two patients level 3. All patients successfully underwent <jats:styled-content style=\"fixed-case\">HMII LVAD<\/jats:styled-content> implantation. There was no mortality within the first 30 postoperative days. Postoperative complications included stroke with full neurological recovery (21.7%), mediastinal infection (21.7%), cardiac tamponade or mediastinal collection requiring reopening of the chest (39.1%), cardiac arrhythmia (13.0%), and pump thrombosis with pump replacement (4.3%). All patients were discharged from hospital after <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content> implantation. Three patients experienced driveline infections during outpatient follow\u2010up. There were 19 readmissions due to the following conditions: sub\u2010therapeutic anticoagulation (13.0%), gastrointestinal bleeding (13.0%), suspected pump thrombosis (13.0%), transient ischemic attack (8.7%), arrhythmia (8.7%), congestive cardiac failure due to severe aortic regurgitation (8.7%), right ventricular failure (4.3%), rhabdomyolysis (4.3%), and hematuria (4.3%). Post\u2010<jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content> implantation, 20 patients were functionally New York Heart Association (<jats:styled-content style=\"fixed-case\">NYHA<\/jats:styled-content>) class I, while 3 reported <jats:styled-content style=\"fixed-case\">NYHA III<\/jats:styled-content> symptoms. Three patients were successfully bridged to heart transplantation. One patient was successfully explanted 11 months after <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content> implantation. There were two mortalities during the follow\u2010up period. The average duration of <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content> support was 522 days (range 47 to 1316 days). The <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>eart<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ate <jats:styled-content style=\"fixed-case\">II LVAD<\/jats:styled-content> has proven to be effective in our Asian population. Driveline infection rate remains low even in the tropical hot, humid climate in <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ingapore. With more patients ending up on extended periods of <jats:styled-content style=\"fixed-case\">LVAD<\/jats:styled-content> support, increased emphasis in the detection and management of long\u2010term complications of ventricular assist devices will be needed.<\/jats:p>","DOI":"10.1111\/aor.12247","type":"journal-article","created":{"date-parts":[[2014,1,7]],"date-time":"2014-01-07T07:07:01Z","timestamp":1389078421000},"page":"543-548","source":"Crossref","is-referenced-by-count":17,"title":["Use of Left Ventricular Assist Device (<scp>H<\/scp>eart<scp>M<\/scp>ate <scp>II<\/scp>): A <scp>S<\/scp>ingapore Experience"],"prefix":"10.1111","volume":"38","author":[{"given":"Choon Pin","family":"Lim","sequence":"first","affiliation":[{"name":"National Heart Centre Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cumaraswamy","family":"Sivathasan","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teing Ee","family":"Tan","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong Hee","family":"Lim","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Lee","family":"Kerk","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Kheng Leng","family":"Sim","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2008.09.006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.11.026"},{"key":"e_1_2_6_4_1","unstructured":"Ministry of Health Singapore.The Human Organ Transplant Act.2004."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012175"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909938"},{"key":"e_1_2_6_7_1","unstructured":"KirklinJK NaftelDC MyersSL et\u2009al.INTERMACS Quarterly Statistical Report 2012 Third Quarter. 19 Dec2012."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.06.028"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12158"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.6.642"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs483"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.128132"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.118274"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(97)70416-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.11.020"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.055"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.11.066"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.09.098"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.01.011"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(03)01301-1"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2006.10.004"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(99)00229-8"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.08.021"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12247","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:32:23Z","timestamp":1696465943000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,7]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/aor.12247"],"URL":"https:\/\/doi.org\/10.1111\/aor.12247","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,7]]}}}