{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T10:42:47Z","timestamp":1786272167592,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T00:00:00Z","timestamp":1390176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T00:00:00Z","timestamp":1390176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Abstract<\/jats:title>\n \n This retrospective cohort study evaluates the effect of chronic antimicrobial suppression (\n CAS<\/jats:styled-content>\n ) therapy on clinical outcomes in patients with continuous\u2010flow left ventricular assist devices (\n CF<\/jats:styled-content>\n \u2010\n LVAD<\/jats:styled-content>\n s) and a history of device\u2010related infection. Patients with\n CF<\/jats:styled-content>\n \u2010\n LVAD<\/jats:styled-content>\n implantation between\n J<\/jats:styled-content>\n anuary 2008 and\n A<\/jats:styled-content>\n ugust 2011 who received systemic\n CAS<\/jats:styled-content>\n after index antibiotic treatment of a device\u2010related infection were included. Chronic suppression was defined as continuation of antibiotics for longer than 6 weeks after the index infection. Standard\n I<\/jats:styled-content>\n nternational\n S<\/jats:styled-content>\n ociety for\n H<\/jats:styled-content>\n eart and\n L<\/jats:styled-content>\n ung\n T<\/jats:styled-content>\n ransplantation definitions were used. The primary outcome is failure of\n CAS<\/jats:styled-content>\n , defined as a clinical deterioration resulting in the need for transition from oral to intravenous (\n IV<\/jats:styled-content>\n ) therapy or a need to change to a different\n IV<\/jats:styled-content>\n antibiotic, elevation to status 1\n A<\/jats:styled-content>\n on the transplant list as a result of ongoing infection, or device\/driveline exchange. Of 140 patients screened, 16 patients were included (69% male, 63%\n A<\/jats:styled-content>\n frican\n A<\/jats:styled-content>\n merican, median age 52 years). The driveline was the most common site of infection (69%). Organisms isolated included Gram\u2010positive cocci (\n n<\/jats:italic>\n \u2009=\u20097), Gram\u2010negative bacilli (\n n<\/jats:italic>\n \u2009=\u200910), and\n Candida<\/jats:italic>\n (\n n<\/jats:italic>\n \u2009=\u20091). Oral trimethoprim\/sulfamethoxazole treatment was most commonly used for suppression (37.5%). Failure of CAS occurred in 5\/16 (31%) patients after a mean time of 175 days on therapy (range 10\u2013598). The majority of failures (60%) required device exchanges. Side effects of nausea, vomiting, or diarrhea were reported in three patients; all required changes in oral suppression regimen.\n Clostridium difficile<\/jats:italic>\n infection was noted in two patients. These results, which must be confirmed by a larger analysis, suggest that one\u2010third of\n CF<\/jats:styled-content>\n \u2010\n LVAD<\/jats:styled-content>\n patients may develop recurrent infections while on\n CAS<\/jats:styled-content>\n therapy.\n <\/jats:p>","DOI":"10.1111\/aor.12254","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T02:26:41Z","timestamp":1390184801000},"page":"875-879","source":"Crossref","is-referenced-by-count":46,"title":["Clinical Outcomes Associated With Chronic Antimicrobial Suppression Therapy in Patients With Continuous\u2010Flow Left Ventricular Assist Devices"],"prefix":"10.1111","volume":"38","author":[{"given":"Douglas L.","family":"Jennings","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice Nova Southeastern University Fort Lauderdale USA"},{"name":"Jackson Memorial Hospital Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuvrat","family":"Chopra","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services St. John Hospital and Medical Center Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Chambers","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Services Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Henry Ford Hospital Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.06.030"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.12.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.04.093"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.09.041"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.08.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.01.011"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit536"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.09.013"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.01.717"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.05.004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.128132"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2007.02.044"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.09.011"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.05.074"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.05.006"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12254","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aor.12254","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T09:58:51Z","timestamp":1786269531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,20]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/aor.12254"],"URL":"https:\/\/doi.org\/10.1111\/aor.12254","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,20]]}}}