{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T10:42:44Z","timestamp":1786272164815,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T00:00:00Z","timestamp":1392940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T00:00:00Z","timestamp":1392940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["PITN-GA-2009-238113"],"award-info":[{"award-number":["PITN-GA-2009-238113"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      According to a number of clinical studies, coronary aspiration catheters are useful tools to remove a thrombus (blood clot) blocking a coronary artery. However, these thrombectomy devices may fail to remove the blood clot entirely. Few studies have been devoted to a systematic analysis of factors affecting clot aspiration. The geometric characteristics of the aspiration catheter, the physical properties of the thrombus, and the applied vacuum pressure are crucial parameters. In this study, the aspiration of a blood clot blocking a coronary bifurcation is computationally simulated. The clot is modeled as a highly viscous fluid, and a two\u2010phase (blood and clot) problem is solved. The effects of geometric variations in the tip of the coronary catheter, including lateral hole size and location, are investigated considering different aspiration pressures and clot viscosities. A\n                      <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\n                      ird\u2013\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      arreau model is adopted for blood viscosity, while a power law model is used to describe the clot rheology. Computational results for blood clot aspiration show that the presence of holes in the lateral part of the tip of the catheter can be beneficial depending on clot viscosity, hole features, and applied aspiration pressure. In general, the holes are beneficial when the clot viscosity is low, while aspiration catheters without any extra lateral holes exhibit better performance for higher clot viscosity. However, when higher aspiration pressures are applied, the catheters tend to behave relatively similarly in removing clots with various viscosities, reducing the role of the clot viscosity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/aor.12274","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T12:27:52Z","timestamp":1393244872000},"page":"845-855","source":"Crossref","is-referenced-by-count":12,"title":["Possible Benefits of Catheters With Lateral Holes in Coronary Thrombus Aspiration: A Computational Study for Different Clot Viscosities and Vacuum Pressures"],"prefix":"10.1111","volume":"38","author":[{"given":"Sajjad","family":"Soleimani","sequence":"first","affiliation":[{"name":"Laboratory of Biological Structure Mechanics Department of Chemistry, Materials, and Chemical Engineering \u201cGiulio Natta\u201d Politecnico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Dubini","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Structure Mechanics Department of Chemistry, Materials, and Chemical Engineering \u201cGiulio Natta\u201d Politecnico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Pennati","sequence":"additional","affiliation":[{"name":"Laboratory of Biological Structure Mechanics Department of Chemistry, Materials, and Chemical Engineering \u201cGiulio Natta\u201d Politecnico di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706416"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.07.018"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20471"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20184"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.11.014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn389"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.23214"},{"key":"e_1_2_8_9_1","first-page":"487","article-title":"Comparison of the in vitro performance of 6 and 7 French aspiration catheters","volume":"2","author":"Hara H","year":"2007","journal-title":"EuroIntervention"},{"key":"e_1_2_8_10_1","first-page":"186424","article-title":"Comparison of the effectiveness of three methods of recanalization in a model of the middle cerebral artery: thrombus aspiration via a 4F catheter, thrombus aspiration via the GP thromboaspiration device, and mechanical thrombectomy using the Solitaire thrombectomy device","volume":"2011","author":"Tennuci C","year":"2011","journal-title":"Stroke Res Treat"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2009.00770.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-22586-4_64"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0037549712463418"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","unstructured":"RomeroG MartinezML FelezJ.Applicability of the GP device to the circle of Willis arteries by using a mathematical model. Presented at 13th International Conference on Computer Modelling and Simulation (UKSim) Cambridge UK March 30\u2013April 1 2011.","DOI":"10.1109\/UKSIM.2011.19"},{"key":"e_1_2_8_15_1","first-page":"317","article-title":"Feasibility of sequential thrombus aspiration and filter distal protection in the management of very high thrombus burden lesions","volume":"19","author":"Burzotta F","year":"2007","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-009-9546-y"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-1991-283-415"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2003.09.016"},{"key":"e_1_2_8_19_1","unstructured":"SoleimaniamiriS.Coronary clot removal by means of aspiration catheter: a numerical and experimental fluid dynamic study.PhD thesis Politecnico di Milano Milan Italy 2013."},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.33549\/physiolres.931306","article-title":"Temperature dependence of blood surface tension","volume":"56","author":"Rosina J","year":"2007","journal-title":"Physiol Res"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.03.009"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.551705"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.09.077"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.211.2.r99ma06433"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-22586-4_54"},{"key":"e_1_2_8_26_1","unstructured":"BalossinoR.A computational study of minimally\u2010invasive devices for the treatment of coronary disease. PhD thesis Politecnico di Milano Milan Italy 2007."}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12274","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/aor.12274","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T09:58:49Z","timestamp":1786269529000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,21]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/aor.12274"],"URL":"https:\/\/doi.org\/10.1111\/aor.12274","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,21]]}}}