{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T05:10:45Z","timestamp":1696396245704},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:00:00Z","timestamp":1398038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>Cardiopulmonary bypass (<jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>) elicits a systemic inflammatory response. Our previous reports revealed that prophylactic sivelestat administration at <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> initiation suppresses the postoperative acute inflammatory response due to <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> in pediatric cardiac surgery. The purpose of this study was to compare the effects of sivelestat administration before <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> and at <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> initiation in patients undergoing pediatric open\u2010heart surgery. Twenty consecutive patients weighing 5\u201310\u2009kg and undergoing ventricular septal defect closure with <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> were divided into pre\u2010<jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200910) and control (<jats:italic>n<\/jats:italic>\u2009=\u200910) groups. Patients in the pre\u2010<jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> group received a 24\u2009h continuous intravenous infusion of 0.2\u2009mg\/kg\/h sivelestat starting at the induction of anesthesia and an additional 0.1\u2009mg\/100\u2009mL during <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> priming. Patients in the control group received a 24\u2010h continuous intravenous infusion of 0.2\u2009mg\/kg\/h sivelestat starting at the commencement of <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>. Blood samples were tested. Clinical variables including blood loss, water balance, systemic vascular resistance index, and the ratio between partial pressure of oxygen and fraction of inspired oxygen (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content> ratio) were assessed. White blood cell count and neutrophil count as well as C\u2010reactive protein levels were significantly lower in the pre\u2010<jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> group according to repeated two\u2010way analysis of variance, whereas platelet count was significantly higher. During <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>, mixed venous oxygen saturation remained significantly higher and lactate levels lower in the pre\u2010<jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> group. Postoperative alanine aminotransferase and blood urea nitrogen levels were significantly lower in the pre\u2010<jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> group than in the control group. The <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content> ratio was significantly higher in the pre\u2010<jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> group than in the control group. Fluid load requirement was significantly lower in the pre\u2010<jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> group.Administration of sivelestat before <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> initiation is more effective than administration at initiation for the suppression of inflammatory responses due to <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> in pediatric open\u2010heart surgery, with this effect being confirmed by clinical evidence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/aor.12311","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T07:48:19Z","timestamp":1398066499000},"page":"1018-1023","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Additional Preoperative Administration of the Neutrophil Elastase Inhibitor Sivelestat on Perioperative Inflammatory Response After Pediatric Heart Surgery With Cardiopulmonary 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