{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:17:37Z","timestamp":1775175457869,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T00:00:00Z","timestamp":1400544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>The S<\/jats:styled-content>ynergy M<\/jats:styled-content>icro\u2010pump is the smallest implantable left ventricular assist device (LVAD<\/jats:styled-content>) and provides partial flow support up to 4.25\u2009L<\/jats:styled-content>\/min. It was shown that early intervention with this device can provide substantial benefits to patients with severe heart failure not yet sick enough for a full\u2010support LVAD<\/jats:styled-content>. However, as it can be inserted via small incisions with no need for sternotomy or cardiopulmonary bypass, it might be beneficial for selected high\u2010risk patients. The aim of this study was to evaluate the efficacy of the S<\/jats:styled-content>ynergy M<\/jats:styled-content>icro\u2010pump in patients in INTERMACS<\/jats:styled-content> class 1\u20132. From F<\/jats:styled-content>ebruary 2012 to A<\/jats:styled-content>ugust 2013, 13 patients with severe heart failure were supported with the S<\/jats:styled-content>ynergy P<\/jats:styled-content>ocket M<\/jats:styled-content>icro\u2010pump. Patients were divided into two groups according to INTERMACS<\/jats:styled-content> class: the high\u2010risk group (INTERMACS<\/jats:styled-content> class 1\u20132) and the low\u2010risk group (INTERMACS<\/jats:styled-content> class 3\u20134). There were seven patients in INTERMACS<\/jats:styled-content> class 1\u20132 and six in INTERMACS<\/jats:styled-content> class 3\u20134. Patient demographics, perioperative characteristics, and postoperative outcomes were compared. There were no statistically significant differences in patient demographics, and mean support time was 108\u2009\u00b1\u2009114 days in the high\u2010risk group and 238\u2009\u00b1\u2009198 days in the low\u2010risk group. Also, there were no significant differences in perioperative characteristics or in the rate of postoperative adverse events. The overall survival was comparable between the two groups (one late death in each group, log\u2010rank P<\/jats:italic><\/jats:styled-content>\u2009=\u20090.608). Two patients from the high\u2010risk group were upgraded to a full\u2010support LVAD<\/jats:styled-content> (P<\/jats:italic><\/jats:styled-content>\u2009=\u20090.462) after 65\u2009\u00b1\u200984.9 days of mean support. One patient from the high\u2010risk group and two patients from the low\u2010risk group were successfully transplanted (P<\/jats:italic><\/jats:styled-content>\u2009=\u20090.559). The use of the S<\/jats:styled-content>ynergy M<\/jats:styled-content>icro\u2010pump in INTERMACS<\/jats:styled-content> 1\u20132 patients is feasible and is associated with similar postoperative outcome as in patients in INTERMACS<\/jats:styled-content> 3\u20134. Carefully selected patients with severe heart failure could benefit due to the small size of the pump; however, further studies and medium\u2010term follow\u2010up are required.<\/jats:p>","DOI":"10.1111\/aor.12316","type":"journal-article","created":{"date-parts":[[2014,5,20]],"date-time":"2014-05-20T05:04:42Z","timestamp":1400562282000},"page":"118-125","source":"Crossref","is-referenced-by-count":8,"title":["First Experience With the S<\/scp>ynergy M<\/scp>icro\u2010P<\/scp>ump in Patients in INTERMACS<\/scp> Class 1\u20132 as a Bridge to Transplantation: Pushing the Limits?"],"prefix":"10.1111","volume":"39","author":[{"given":"Anton","family":"Sabashnikov","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Transplantation and Mechanical Circulatory Support"},{"name":"Department of Cardiothoracic Surgery University Hospital of Cologne Cologne"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aron\u2010Frederik","family":"Popov","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher T.","family":"Bowles","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Transplantation and Mechanical Circulatory Support"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Weymann","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Transplantation and Mechanical Circulatory Support"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5533-3089","authenticated-orcid":false,"given":"Prashant N.","family":"Mohite","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Transplantation and Mechanical Circulatory Support"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Wahlers","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital of Cologne Cologne"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Wittwer","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery University Hospital of Cologne Cologne"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartlomiej","family":"Zych","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Transplantation and Mechanical Circulatory Support"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Garcia\u2010Saez","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Transplantation and Mechanical Circulatory Support"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil P.","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Transplantation and Mechanical Circulatory Support"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javid","family":"Fatullayev","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Transplantation and Mechanical Circulatory Support"},{"name":"Department of Cardiothoracic Surgery University Hospital of Cologne Cologne"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Amrani","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Transplantation and Mechanical Circulatory Support"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas R.","family":"Banner","sequence":"additional","affiliation":[{"name":"Department of Heart Failure and Transplant Medicine Royal Brompton & Harefield NHS Foundation Trust Harefield, Middlesex UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Seidler","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University of Goettingen Goettingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Unsoeld","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology University of Goettingen Goettingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bireta","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich A.","family":"Schoendube","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 R.","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of 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