{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:31:20Z","timestamp":1761895880930,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T00:00:00Z","timestamp":1404864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011892","name":"Kaohsiung Chang Gung Memorial Hospital","doi-asserted-by":"crossref","award":["CMRPG890171"],"award-info":[{"award-number":["CMRPG890171"]}],"id":[{"id":"10.13039\/501100011892","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>Protein\u2010energy wasting (PEW<\/jats:styled-content>) contributes to mortality in hemodialysis (HD<\/jats:styled-content>) patients. Adipokines regulate energy homeostasis and body weight. Circulating gelsolin can modulate inflammation and is correlated with HD<\/jats:styled-content> mortality. Whether adipokines and gelsolin play important roles in PEW<\/jats:styled-content> remains unclear. Based on the criteria proposed by the I<\/jats:styled-content>nternational S<\/jats:styled-content>ociety of R<\/jats:styled-content>enal N<\/jats:styled-content>utrition and M<\/jats:styled-content>etabolism, we examined the associations between PEW<\/jats:styled-content> and biomarkers (gelsolin, leptin, adiponectin, interleukin\u20106, tumor necrosis factor alpha [TNF<\/jats:styled-content>\u2010\u03b1]) in 188 stable HD patients. Patients with PEW<\/jats:styled-content> had significantly lower serum leptin levels, and tended to have higher adiponectin, TNF<\/jats:styled-content>\u2010\u03b1, and lower gelsolin levels. Logistic regression analysis revealed that gelsolin, leptin, adiponectin, and blood urea nitrogen were independently associated with PEW<\/jats:styled-content> score. Serum creatinine, TNF<\/jats:styled-content>\u2010\u03b1, gender, renin\u2010angiotensin system (RAS<\/jats:styled-content>) blockade, and lipid\u2010lowering agents were not associated with PEW<\/jats:styled-content> score. Patients on lipid\u2010lowering agents had lower PEW<\/jats:styled-content> scores and those with RAS<\/jats:styled-content> blockade had higher PEW<\/jats:styled-content> scores. Our study confirms that gelsolin, adiponectin, and leptin are significant associates with PEW<\/jats:styled-content> in HD<\/jats:styled-content> patients. Further understanding of how these factors contribute to PEW<\/jats:styled-content> may help design novel therapeutic strategies for PEW<\/jats:styled-content> in chronic kidney disease.<\/jats:p>","DOI":"10.1111\/aor.12342","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T03:29:46Z","timestamp":1404962986000},"page":"150-155","source":"Crossref","is-referenced-by-count":10,"title":["Gelsolin and Adipokines Are Associated With Protein\u2010Energy Wasting in Hemodialysis Patients"],"prefix":"10.1111","volume":"39","author":[{"given":"Terry Ting\u2010Yu","family":"Chiu","sequence":"first","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang\u2010Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang\u2010Chih","family":"Liao","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang\u2010Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Chin","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang\u2010Gung University College of Medicine Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po\u2010Shun","family":"Lee","sequence":"additional","affiliation":[{"name":"Translational Medicine Brigham and Women's Hospital, Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwee\u2010Yeong","family":"Ng","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital Chang\u2010Gung University College of Medicine Kaohsiung 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