{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:43:07Z","timestamp":1768070587224,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T00:00:00Z","timestamp":1421107200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"This project was supported by a contract between the Xenios AG, Germany and Penn State Hershey College of Medicine, Hershey, PA, USA","award":["contract #140678"],"award-info":[{"award-number":["contract #140678"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study is to investigate the impact of every component of extracorporeal life support (<jats:styled-content style=\"fixed-case\">ECLS<\/jats:styled-content>) circuit on hemodynamic energy transmission in terms of energy equivalent pressure (<jats:styled-content style=\"fixed-case\">EEP<\/jats:styled-content>), total hemodynamic energy (<jats:styled-content style=\"fixed-case\">THE<\/jats:styled-content>), and surplus hemodynamic energy (<jats:styled-content style=\"fixed-case\">SHE<\/jats:styled-content>) under nonpulsatile and pulsatile modes in a novel <jats:styled-content style=\"fixed-case\">ECLS<\/jats:styled-content> system. The <jats:styled-content style=\"fixed-case\">ECLS<\/jats:styled-content> circuit consisted of i\u2010cor diagonal pump and console (<jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>enios <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>eilbronn, <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>ermany), an <jats:styled-content style=\"fixed-case\">iLA<\/jats:styled-content> membrane ventilator (<jats:styled-content style=\"fixed-case\">X<\/jats:styled-content>enios <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>), an 18 <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>r femoral arterial cannula, a 23\/25 <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>r femoral venous cannula, and 3\/8\u2010in <jats:styled-content style=\"fixed-case\">ID<\/jats:styled-content> arterial and venous tubing. The circuit was primed with lactated <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>inger's solution and human whole blood (hematocrit 33%). All trials were conducted under room temperature at the flow rates of 1\u20134\u2009L\/min (1\u2009L\/min increments). The pulsatile flow settings were set at pulsatile frequency of 75 beats per minute and differential speed values of 1000\u20134000\u2009rpm (1000\u2009rpm increments). Flow and pressure data were collected using a custom\u2010based data acquisition system. <jats:styled-content style=\"fixed-case\">EEP<\/jats:styled-content> was significantly higher than mean arterial pressure in all experimental conditions under pulsatile flow (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). <jats:styled-content style=\"fixed-case\">THE<\/jats:styled-content> was also increased under pulsatile flow compared with the nonpulsatile flow (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Under pulsatile flow conditions, <jats:styled-content style=\"fixed-case\">SHE<\/jats:styled-content> was significantly higher and increased differential rpm resulted in significantly higher <jats:styled-content style=\"fixed-case\">SHE<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). There was no <jats:styled-content style=\"fixed-case\">SHE<\/jats:styled-content> generated under nonpulsatile flow. Energy loss depending on the circuit components was almost similar in both perfusion modes at all different flow rates. The pressure drops across the oxygenator were 3.8\u201324.9\u2009mm\u2009<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>g, and the pressure drops across the arterial cannula were 19.3\u2013172.6\u2009mm\u2009<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>g at the flow rates of 1\u20134\u2009L\/min. Depending on the pulsatility setting, <jats:styled-content style=\"fixed-case\">i<\/jats:styled-content>\u2010cor <jats:styled-content style=\"fixed-case\">ECLS<\/jats:styled-content> system generates physiological quality pulsatile flow without increasing the mean circuit pressure. The <jats:styled-content style=\"fixed-case\">iLA<\/jats:styled-content> membrane ventilator is a low\u2010resistance oxygenator, and allows more hemodynamic energy to be delivered to the patient under pulsatile mode. The 18\u2009<jats:styled-content style=\"fixed-case\">Fr<\/jats:styled-content> femoral arterial cannula has acceptable pressure drops under nonpulsatile and pulsatile modes. Further in vivo studies are warranted to confirm these results.<\/jats:p>","DOI":"10.1111\/aor.12430","type":"journal-article","created":{"date-parts":[[2015,1,13]],"date-time":"2015-01-13T21:28:01Z","timestamp":1421184481000},"page":"59-66","source":"Crossref","is-referenced-by-count":34,"title":["In Vitro Hemodynamic Evaluation of a Novel Pulsatile Extracorporeal Life Support System: Impact of Perfusion Modes and Circuit Components on Energy Loss"],"prefix":"10.1111","volume":"39","author":[{"given":"Shigang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pediatrics Penn State Hershey Pediatric Cardiovascular Research Center Penn State Milton S. Hershey Medical Center Penn State Hershey College of Medicine Penn State Hershey Children's Hospital  Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen R.","family":"Kunselman","sequence":"additional","affiliation":[{"name":"Department of Public and Health Sciences Penn State Hershey Pediatric Cardiovascular Research Center Penn State Milton S. Hershey Medical Center Penn State Hershey College of Medicine Penn State Hershey Children's Hospital  Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph B.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Penn State Hershey Pediatric Cardiovascular Research Center Penn State Milton S. Hershey Medical Center Penn State Hershey College of Medicine Penn State Hershey Children's Hospital  Hershey PA USA"},{"name":"Department of Surgery Penn State Hershey Pediatric Cardiovascular Research Center Penn State Milton S. Hershey Medical Center Penn State Hershey College of Medicine Penn State Hershey Children's Hospital  Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akif","family":"\u00dcndar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Penn State Hershey Pediatric Cardiovascular Research Center Penn State Milton S. Hershey Medical Center Penn State Hershey College of Medicine Penn State Hershey Children's Hospital  Hershey PA USA"},{"name":"Department of Surgery Penn State Hershey Pediatric Cardiovascular Research Center Penn State Milton S. Hershey Medical Center Penn State Hershey College of Medicine Penn State Hershey Children's Hospital  Hershey PA USA"},{"name":"Department of Bioengineering Penn State Hershey Pediatric Cardiovascular Research Center Penn State Milton S. Hershey Medical Center Penn State Hershey College of Medicine Penn State Hershey Children's Hospital  Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,13]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Extracorporeal Life Support Organization (ELSO).January 2014 International Summary of ELSO Registry Report.2014. Ann Arbor Michigan."},{"key":"e_1_2_8_3_1","article-title":"Pulsatile cardiopulmonary bypass and renal function in elderly patients undergoing aortic valve surgery","author":"Milano AD","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01191.2011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.05.065"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2007.06.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12312"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12015"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes021"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1966.01330050034005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1198\/jasa.2009.0116"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659111401673"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12181"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12430","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:02:28Z","timestamp":1695553348000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/aor.12430"],"URL":"https:\/\/doi.org\/10.1111\/aor.12430","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}