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This study has shown that the descending aorta can be a promising location to install an implantable mechanical circulatory support with minimally invasive surgery. Herein, the hemodynamic effect of an in\u2010house prototyped pump implanted in the descending aorta was investigated numerically as well as experimentally. The objective of the experimental study is met by using the in\u2010house simulator of the cardiovascular loop replicating congestive heart failure conditions. The objective of the numerical study was met by using the modified version of the concentrated lumped parameter model developed by the same team. The results show that the pump placement in the descending aorta can lead to an improvement in pulsatility. The pressure drop, generated at the upstream of the pump, facilitates the cardiac output as a result of after\u2010load reduction, but at the same time, it induces a slight drop in the carotid as well as the coronary perfusion. The pressure rise, generated at the downstream of the pump, improves the blood perfusion in the renal circulation.<\/jats:p>","DOI":"10.1111\/aor.12431","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T11:49:03Z","timestamp":1427197743000},"page":"502-513","source":"Crossref","is-referenced-by-count":16,"title":["Numerical and In Vitro Investigation of a Novel Mechanical Circulatory Support Device Installed in the Descending Aorta"],"prefix":"10.1111","volume":"39","author":[{"given":"Mohammad Amin","family":"Rezaienia","sequence":"first","affiliation":[{"name":"School of Engineering and Materials Science Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akbar","family":"Rahideh","sequence":"additional","affiliation":[{"name":"School of Electrical and Electronic Engineering Shiraz University of Technology  Shiraz 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