{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:56:48Z","timestamp":1779364608858,"version":"3.53.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:00:00Z","timestamp":1422316800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Apolipoprotein <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">apoE<\/jats:styled-content>) may play a critical role in modulating the response to neurological injury after cardiopulmonary bypass (<jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>) in children. Plasma samples were collected from 38 pediatric patients. Half of the patients received nonpulsatile flow and the other half underwent pulsatile flow during <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>. Plasma samples were collected at three time points: at baseline prior to incision (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>1), 1\u2009h after <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>2), and 24\u2009h after <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>3). The study included 38 pediatric patients undergoing heart surgery (mean age 2.5\u2009\u00b1\u20092.1 years). Baseline <jats:styled-content style=\"fixed-case\">apoE<\/jats:styled-content> levels were low (&lt;30\u2009\u03bcg\/mL) in 21 patients (55%). Apo<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> levels were significantly decreased at 1\u2009h after <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> compared with baseline (22\u2009\u00b1\u200914\u2009vs. 34\u2009\u00b1\u200918\u2009\u03bcg\/mL, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). At 24\u2009h after <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">apoE<\/jats:styled-content> levels were significantly increased compared with baseline (47\u2009\u00b1\u200925 vs. 34\u2009\u00b1\u200918\u2009\u03bcg\/mL, <jats:italic>P<\/jats:italic>\u2009=\u20090.002). Pulsatile mode was associated with lower apo<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> levels at 24\u2009h after <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> compared with nonpulsatile mode (38\u2009\u00b1\u200914 vs. 57\u2009\u00b1\u200929\u2009\u03bcg\/mL, <jats:italic>P<\/jats:italic>\u2009=\u20090.018). Apo<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> levels correlated negatively with pump time (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.525, <jats:italic>P<\/jats:italic>\u2009=\u20090.021) and cross\u2010clamp time (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.464, <jats:italic>P<\/jats:italic>\u2009=\u20090.045) at 24\u2009h following <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content> for the nonpulsatile group but not for the pulsatile group. In this cohort of young children with congenital heart disease, baseline <jats:styled-content style=\"fixed-case\">apoE<\/jats:styled-content> levels were low in the majority of patients prior to surgery. Apo<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> levels decreased further at 1\u2009h after <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>, and then significantly increased by 24\u2009h. The mode of perfusion and the duration of pump time and clamp time influence the apo<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> levels after <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>. An improved understanding of these mechanisms may translate into the development of new techniques to improve the clinical outcomes after pediatric <jats:styled-content style=\"fixed-case\">CPB<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/aor.12444","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T03:22:31Z","timestamp":1422415351000},"page":"28-33","source":"Crossref","is-referenced-by-count":19,"title":["<scp>A<\/scp>polipoprotein <scp>E<\/scp> Levels in Pediatric Patients Undergoing Cardiopulmonary Bypass"],"prefix":"10.1111","volume":"39","author":[{"given":"Mehmet","family":"A\u011dirba\u015fli","sequence":"first","affiliation":[{"name":"Department of Cardiology Marmara University College of Medicine  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology, Penn State Milton S. Hershey Medical Center, Penn State Hershey College of Medicine Penn State Hershey Children's Hospital  Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyang","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Microbiology &amp; Immunology, Penn State Milton S. Hershey Medical Center, Penn State Hershey College of Medicine Penn State Hershey Children's Hospital  Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigang","family":"Wang","sequence":"additional","affiliation":[{"name":"Penn State Hershey Pediatric Cardiovascular Research Center, Department of Pediatrics, Public Health and Sciences, Surgery and Bioengineering, Penn State Milton S. Hershey Medical Center, Penn State Hershey College of Medicine Penn State Hershey Children's Hospital  Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen R.","family":"Kunselman","sequence":"additional","affiliation":[{"name":"Penn State Hershey Pediatric Cardiovascular Research Center, Department of Pediatrics, Public Health and Sciences, Surgery and Bioengineering, Penn State Milton S. Hershey Medical Center, Penn State Hershey College of Medicine Penn State Hershey Children's Hospital  Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Clark","sequence":"additional","affiliation":[{"name":"Penn State Hershey Pediatric Cardiovascular Research Center, Department of Pediatrics, Public Health and Sciences, Surgery and Bioengineering, Penn State Milton S. Hershey Medical Center, Penn State Hershey College of Medicine Penn State Hershey Children's Hospital  Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Myers","sequence":"additional","affiliation":[{"name":"Penn State Hershey Pediatric Cardiovascular Research Center, Department of Pediatrics, Public Health and Sciences, Surgery and Bioengineering, Penn State Milton S. Hershey Medical Center, Penn State Hershey College of Medicine Penn State Hershey Children's Hospital  Hershey PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akif","family":"\u00dcndar","sequence":"additional","affiliation":[{"name":"Penn State Hershey Pediatric Cardiovascular Research Center, Department of Pediatrics, Public Health and Sciences, Surgery and Bioengineering, Penn State Milton S. 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