{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:21Z","timestamp":1787013861620,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Abstract<\/jats:title>\n \n As the name reveals, acetate\u2010free biofiltration (\n AFB<\/jats:styled-content>\n ) is featured by lack of acetate and this would seem to allow better hemodynamic stability. However,\n AFB<\/jats:styled-content>\n also has a unique characteristic of carbon dioxide (\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n )\u2010free dialysate, whereas all other modern dialysis techniques imply an overload of\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n from dialysate to the patient. This notwithstanding the role of\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n in tolerance to dialysis treatment, both\n AFB<\/jats:styled-content>\n and all other dialysis techniques seem not investigated in due depth. Specifically, the amount of\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n coming back to the patient's bloodstream during\n AFB<\/jats:styled-content>\n and bicarbonate dialysis (\n BD<\/jats:styled-content>\n ) is unknown. We measured partial pressure of\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n (p\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n ) in blood samples withdrawn from the venous line of the extracorporeal circuit during\n BD<\/jats:styled-content>\n and subsequently during\n AFB<\/jats:styled-content>\n in 22 stable chronic hemodialysis outpatients. The amount of\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n coming back to the patient's bloodstream is higher in\n BD<\/jats:styled-content>\n (59.1\u2009\u00b1\u20094.0\u2009mmol\/L) than in\n AFB (4<\/jats:styled-content>\n 2.8\u2009\u00b1\u20094.5\u2009mmol\/L,\n P<\/jats:italic>\n \u2009<\u20090.0001). Such difference exceeds 30%. Moreover, shifting from\n BD<\/jats:styled-content>\n to\n AFB<\/jats:styled-content>\n shows, notably for each patient, the reduction of p\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n toward physiological values.\n BD<\/jats:styled-content>\n implies\n CO<\/jats:styled-content>\n 2<\/jats:sub>\n overload from dialysate, whereas\n AFB<\/jats:styled-content>\n does not. Further studies are required to evaluate if\n AFB<\/jats:styled-content>\n would be the most appropriate dialysis technique in patients affected by chronic, but especially acute, lung diseases.\n <\/jats:p>","DOI":"10.1111\/aor.12477","type":"journal-article","created":{"date-parts":[[2015,5,2]],"date-time":"2015-05-02T00:22:01Z","timestamp":1430526121000},"page":"960-964","source":"Crossref","is-referenced-by-count":11,"title":["Carbon Dioxide and Acetate\u2010Free Biofiltration: A Relationship to be Investigated"],"prefix":"10.1111","volume":"39","author":[{"given":"Marco","family":"Marano","sequence":"first","affiliation":[{"name":"Hemodialysis Unit Maria Rosaria Clinic Pompeii Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"D'Amato","sequence":"additional","affiliation":[{"name":"Hemodialysis Unit Maria Rosaria Clinic Pompeii Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Patriarca","sequence":"additional","affiliation":[{"name":"Hemodialysis Unit Maria Rosaria Clinic Pompeii Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi Michele","family":"Di Nuzzi","sequence":"additional","affiliation":[{"name":"Nephrology & Dialysis Unit San Felice a Cancello Hospital San Felice a Cancello Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gelsomina","family":"Giordano","sequence":"additional","affiliation":[{"name":"Nephrology & Dialysis Unit San Felice a Cancello Hospital San Felice a Cancello Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Iulianiello","sequence":"additional","affiliation":[{"name":"Nephrology & Dialysis Unit San Felice a Cancello Hospital San Felice a Cancello Caserta Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107244"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(96)90165-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/13.4.955"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346293"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.2002.06877.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1681\/ASN.V891431","article-title":"Acetate intolerance is mediated by enhanced synthesis of nitric oxide by endothelial cells","volume":"8","author":"Amore A","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.07.028"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2005.00126.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.162"},{"key":"e_1_2_7_11_1","first-page":"pii: gin\/30.5.8","article-title":"Gas analysis in bicarbonate dialysis","volume":"30","author":"Marano M","year":"2013","journal-title":"G Ital Nefrol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197410000-00006"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc8926"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1982.38"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-6686.2008.00002.x"},{"issue":"61","key":"e_1_2_7_16_1","first-page":"88","article-title":"Insolita indicazione per l'AFB: il paziente ipercapnico. Abstract 54\u00b0 Congresso Nazionale della Societ\u00e0 italiana di Nefrologia. Firenze 25\u201328 Settembre 2013","volume":"30","author":"Patriarca A","year":"2013","journal-title":"G Ital Nefrol"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12477","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T09:21:45Z","timestamp":1695460905000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/aor.12477"],"URL":"https:\/\/doi.org\/10.1111\/aor.12477","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}