{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:12:50Z","timestamp":1787242370190,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T00:00:00Z","timestamp":1436140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015699","name":"Fresenius Medical Care","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015699","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Abstract<\/jats:title>\n \n Peritoneal transport characteristics and residual renal function require regular control and subsequent adjustment of the peritoneal dialysis (\n PD<\/jats:styled-content>\n ) prescription. Prescription models shall facilitate the prediction of the outcome of such adaptations for a given patient. In the present study, the prescription model implemented in the PatientOnLine software was validated in patients requiring a prescription change. This multicenter, international prospective cohort study with the aim to validate a\n PD<\/jats:styled-content>\n prescription model included patients treated with continuous ambulatory peritoneal dialysis. Patients were examined with the peritoneal function test (\n PFT<\/jats:styled-content>\n ) to determine the outcome of their current prescription and the necessity for a prescription change. For these patients, a new prescription was modeled using the PatientOnLine software (Fresenius Medical Care, Bad Homburg, Germany). Two to four weeks after implementation of the new\n PD<\/jats:styled-content>\n regimen, a second\n PFT<\/jats:styled-content>\n was performed. The validation of the prescription model included 54 patients. Predicted and measured peritoneal\n Kt\/V<\/jats:styled-content>\n were 1.52\u2009\u00b1\u20090.31 and 1.66\u2009\u00b1\u20090.35, and total (peritoneal\u2009+\u2009renal)\n Kt\/V<\/jats:styled-content>\n values were 1.96\u2009\u00b1\u20090.48 and 2.06\u2009\u00b1\u20090.44, respectively. Predicted and measured peritoneal creatinine clearances were 42.9\u2009\u00b1\u20098.6 and 43.0\u2009\u00b1\u20098.8\u2009L\/1.73\u2009m\n 2<\/jats:sup>\n \/week and total creatinine clearances were 65.3\u2009\u00b1\u200926.0 and 63.3\u2009\u00b1\u200921.8\u2009L\/1.73\u2009m\n 2<\/jats:sup>\n \/week, respectively. The analysis revealed a\n P<\/jats:styled-content>\n earson's correlation coefficient for peritoneal\n Kt\/V<\/jats:styled-content>\n of 0.911 and\n L<\/jats:styled-content>\n in's concordance coefficient of 0.829. The value of both coefficients was 0.853 for peritoneal creatinine clearance. Predicted and measured daily net ultrafiltration was 0.77\u2009\u00b1\u20090.49\u2009and 1.16\u2009\u00b1\u20090.63\u2009L\/24\u2009h, respectively.\n P<\/jats:styled-content>\n earson's correlation and\n L<\/jats:styled-content>\n in's concordance coefficient were 0.518 and 0.402, respectively. Predicted and measured peritoneal glucose absorption was 125.8\u2009\u00b1\u200938.8 and 79.9\u2009\u00b1\u200930.7\u2009g\/24\u2009h, respectively, and\n P<\/jats:styled-content>\n earson's correlation and\n L<\/jats:styled-content>\n in's concordance coefficient were 0.914 and 0.477, respectively. With good predictability of peritoneal\n Kt\/V<\/jats:styled-content>\n and creatinine clearance, the present model provides support for individual dialysis prescription in clinical practice. Peritoneal glucose absorption and ultrafiltration are less predictable and are likely to be influenced by additional clinical factors to be taken into consideration.\n <\/jats:p>","DOI":"10.1111\/aor.12526","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T05:38:08Z","timestamp":1436161088000},"page":"144-152","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Validation of a Peritoneal Dialysis Prescription Model in the\n P<\/scp>\n atient\n O<\/scp>\n n\n L<\/scp>\n ine Software"],"prefix":"10.1111","volume":"40","author":[{"given":"Emir","family":"Hodzic","sequence":"first","affiliation":[{"name":"Clinic for Internal Diseases University Clinical Center Tuzla Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senija","family":"Rasic","sequence":"additional","affiliation":[{"name":"Clinical Center University Sarajevo Bosnia and Herzegovina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Klein","sequence":"additional","affiliation":[{"name":"Dr. Carol Davila Hospital Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Covic","sequence":"additional","affiliation":[{"name":"University of Medicine \u201cGrigore T Popa\u201d Iasi Romania"},{"name":"\u201cC. I. Parhon\u201d University Hospital Iasi Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulkadir","family":"Unsal","sequence":"additional","affiliation":[{"name":"Sisli Etfal Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel Gil","family":"Cunquero","sequence":"additional","affiliation":[{"name":"General Hospital Jaen Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich C.","family":"Prischl","sequence":"additional","affiliation":[{"name":"Klinikum Wels\u2010Grieskirchen Wels Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelheid","family":"Gauly","sequence":"additional","affiliation":[{"name":"Fresenius Medical Care Bad Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Kalicki","sequence":"additional","affiliation":[{"name":"University Hospital Bern Switzerland"},{"name":"University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik E.","family":"Uehlinger","sequence":"additional","affiliation":[{"name":"University Hospital Bern Switzerland"},{"name":"University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq100"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1177\/089686080602600502","article-title":"Guideline on targets for solute and fluid removal in adult patients on chronic peritoneal dialysis","volume":"26","author":"Lo WK","year":"2006","journal-title":"Perit Dial Int"},{"issue":"9","key":"e_1_2_9_4_1","first-page":"ix24","article-title":"European best practice guidelines for peritoneal dialysis. 7 Adequacy of peritoneal dialysis","volume":"20","author":"Dombros N","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1351307"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00098.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1177\/089686080902900609","article-title":"Peritoneal small solute clearance is nonlinearly related to patient survival in the Australian and New Zealand peritoneal dialysis patient populations","volume":"29","author":"Rumpsfeld M","year":"2009","journal-title":"Perit Dial Int"},{"key":"e_1_2_9_8_1","first-page":"43","article-title":"Computerized urea kinetic modeling to prescribe and monitor delivered Kt\/V (pKt\/V, dKt\/V) in peritoneal dialysis. 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PD ADEQUEST International Study Group","volume":"19","author":"Vonesh EF","year":"1999","journal-title":"Perit Dial Int"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfi344"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.66021.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017148"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1177\/089686080602600408","article-title":"Overfill or ultrafiltration? We need to be clear","volume":"26","author":"Davies SJ","year":"2006","journal-title":"Perit Dial Int"},{"key":"e_1_2_9_23_1","unstructured":"EDTNA\/ERCA.European Guidelines for the Nutritional Care of Adult Renal Patients. Dietitians Special Interest Group October.2002."},{"key":"e_1_2_9_24_1","first-page":"131","article-title":"A simple kinetic model for assessing peritoneal mass transfer in chronic ambulatory peritoneal dialysis","volume":"6","author":"Garred LJ","year":"1983","journal-title":"ASAIO J"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12526","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T07:58:04Z","timestamp":1695542284000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,6]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/aor.12526"],"URL":"https:\/\/doi.org\/10.1111\/aor.12526","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,6]]}}}