{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T09:18:16Z","timestamp":1763457496601,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,8,2]],"date-time":"2015-08-02T00:00:00Z","timestamp":1438473600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007145","name":"Thoratec Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007145","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The hemocompatible properties of rotary blood pumps commonly used in mechanical circulatory support (<jats:styled-content style=\"fixed-case\">MCS<\/jats:styled-content>) are widely unknown regarding specific biocompatibility profiles of different pump technologies. Therefore, we analyzed the hemocompatibility indicating markers of an axial flow and a magnetically levitated centrifugal device within an in vitro mock loop. The <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>eart<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ate <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HM II<\/jats:styled-content>; <jats:italic>n<\/jats:italic>\u2009=\u20093) device and a <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>entri<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ag (<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>; <jats:italic>n<\/jats:italic>\u2009=\u20093) adult pump were investigated in a human whole blood mock loop for 360\u2009min using the <jats:styled-content style=\"fixed-case\">MCS<\/jats:styled-content> devices as a driving component. Blood samples were analyzed by enzyme\u2010linked immunosorbent assay for markers of coagulation, complement system, and inflammatory response. There was a time\u2010dependent activation of the coagulation (thrombin\u2013antithrombin complexes [<jats:styled-content style=\"fixed-case\">TAT<\/jats:styled-content>]), complement (<jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>5b\u20109), and inflammation system (polymorphonuclear [<jats:styled-content style=\"fixed-case\">PMN<\/jats:styled-content>] elastase) in both groups. The mean value of <jats:styled-content style=\"fixed-case\">TAT<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>: 4.0\u2009\u03bcg\/L vs. 29.4\u2009\u03bcg\/L, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; <jats:styled-content style=\"fixed-case\">HM II<\/jats:styled-content>: 4.5\u2009\u03bcg\/L vs. 232.2\u2009\u03bcg\/L, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and <jats:styled-content style=\"fixed-case\">PMN<\/jats:styled-content> elastase (<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>: 53.4\u2009ng\/mL vs. 253.8\u2009ng\/mL, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05; <jats:styled-content style=\"fixed-case\">HM II<\/jats:styled-content>: 28.0\u2009ng\/mL vs. 738.8\u2009ng\/mL, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) significantly increased from baseline until the end of the experiments (360\u2009min). After 360\u2009min, <jats:styled-content style=\"fixed-case\">TAT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PMN<\/jats:styled-content> values were significantly higher in the <jats:styled-content style=\"fixed-case\">HM II<\/jats:styled-content> group compared with the values in the <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> adult group. The values of <jats:styled-content style=\"fixed-case\">SC<\/jats:styled-content>5b\u20109 increased from baseline to 360\u2009min in the <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> group (<jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content>: 141.8\u2009ng\/mL vs. 967.9\u2009ng\/mL, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and the <jats:styled-content style=\"fixed-case\">HM II<\/jats:styled-content> group. However, the increase within the <jats:styled-content style=\"fixed-case\">HM II<\/jats:styled-content> group (97.3 vs. 2462.0, <jats:italic>P<\/jats:italic>\u2009=\u20090.06) and the comparison of the 360\u2010min values between <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> group and <jats:styled-content style=\"fixed-case\">HM II<\/jats:styled-content> group did not reach significance (<jats:italic>P<\/jats:italic>\u2009=\u20090.18). The activation of complement, coagulation, and inflammation system showed a time\u2010dependent manner in both devices. The centrifugal <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> device showed significantly lower activation of coagulation and inflammation than that of the <jats:styled-content style=\"fixed-case\">HM II<\/jats:styled-content> axial flow pump. Both <jats:styled-content style=\"fixed-case\">HM II<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CM<\/jats:styled-content> have demonstrated an acceptable hemocompatibility profile in patients. However, there is a great opportunity to gain a clinical benefit by developing techniques to lower the blood surface interaction within both pump technologies and a magnetically levitated centrifugal pump design might be superior.<\/jats:p>","DOI":"10.1111\/aor.12544","type":"journal-article","created":{"date-parts":[[2015,8,3]],"date-time":"2015-08-03T04:25:08Z","timestamp":1438575908000},"page":"723-728","source":"Crossref","is-referenced-by-count":14,"title":["Hemocompatibility of Axial Versus Centrifugal Pump Technology in Mechanical Circulatory Support Devices"],"prefix":"10.1111","volume":"39","author":[{"given":"David","family":"Schibilsky","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University Medical Center Tuebingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Lenglinger","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University Medical Center Tuebingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meltem","family":"Avci\u2010Adali","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University Medical Center Tuebingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Haller","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University Medical Center Tuebingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University Medical Center Tuebingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Peter","family":"Wendel","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University Medical Center Tuebingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Schlensak","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery University Medical Center Tuebingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3182904a52"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2014.04.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313385"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2009.00900.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1191\/0267659102pf602oa"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.10.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.04.048"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000079"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30614"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12049"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13239-011-0061-7"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e31815dbf66"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000347222"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12544","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T01:10:47Z","timestamp":1695517847000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/aor.12544"],"URL":"https:\/\/doi.org\/10.1111\/aor.12544","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"type":"print","value":"0160-564X"},{"type":"electronic","value":"1525-1594"}],"subject":[],"published":{"date-parts":[[2015,8]]}}}