{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T09:26:10Z","timestamp":1793179570574,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Philadelphia-TriUniversity Consortium","award":["250596"],"award-info":[{"award-number":["250596"]}]},{"name":"American Heart Association Postdoctoral Fellowship","award":["15POST21130007"],"award-info":[{"award-number":["15POST21130007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Artificial Organs"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An intravascular axial flow pump is being developed as a mechanical cavopulmonary assist device for adolescent and adult patients with dysfunctional <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ontan physiology. Coupling computational modeling with experimental evaluation of prototypic designs, this study examined the hydraulic performance of 11 impeller prototypes with blade stagger or twist angles varying from 100 to 600 degrees. A refined range of twisted blade angles between 300 and 400 degrees with 20\u2010degree increments was then selected, and four additional geometries were constructed and hydraulically evaluated. The prototypes met performance expectations and produced 3\u201331\u2009mm\u2009<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>g for flow rates of 1\u20135\u2009L\/min for 6000\u20138000\u2009rpm. A regression analysis was completed with all characteristic coefficients contributing significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). This analysis revealed that the impeller with 400 degrees of blade twist outperformed the other designs. The findings of the numerical model for 300\u2010degree twisted case and the experimental results deviated within approximately 20%. In an effort to simplify the impeller geometry, this work advanced the design of this intravascular cavopulmonary assist device closer to preclinical animal testing.<\/jats:p>","DOI":"10.1111\/aor.12549","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T21:09:52Z","timestamp":1441228192000},"page":"233-242","source":"Crossref","is-referenced-by-count":12,"title":["Pressure\u2013Flow Experimental Performance of New Intravascular Blood Pump Designs for Fontan Patients"],"prefix":"10.1111","volume":"40","author":[{"given":"Steven G.","family":"Chopski","sequence":"first","affiliation":[{"name":"BioCirc Research Laboratory School of Biomedical Engineering, Science, and Health Systems Drexel University  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carson S.","family":"Fox","sequence":"additional","affiliation":[{"name":"BioCirc Research Laboratory School of Biomedical Engineering, Science, and Health Systems Drexel University  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Riddle","sequence":"additional","affiliation":[{"name":"BioCirc Research Laboratory School of Biomedical Engineering, Science, and Health Systems Drexel University  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli L.","family":"McKenna","sequence":"additional","affiliation":[{"name":"BioCirc Research Laboratory School of Biomedical Engineering, Science, and Health Systems Drexel University  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay P.","family":"Patel","sequence":"additional","affiliation":[{"name":"BioCirc Research Laboratory School of Biomedical Engineering, Science, and Health Systems Drexel University  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Rozolis","sequence":"additional","affiliation":[{"name":"BioCirc Research Laboratory School of Biomedical Engineering, Science, and Health Systems Drexel University  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L.","family":"Throckmorton","sequence":"additional","affiliation":[{"name":"BioCirc Research Laboratory School of Biomedical Engineering, Science, and Health Systems Drexel University  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3949"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-1397"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1114\/1.1408930"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2012.12.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(97)70183-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.738559"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.12443"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e3181c5b046"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-010-0159-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e31825d018e"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e31815581ea"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13239-010-0026-2"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.592378"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt461"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01164-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000030"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.pcsu.2014.01.007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2012.12.004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2013.03.003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.10.030"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000685"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2006.02.015"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.06.120"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.12.002"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.02.036"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/2150135111435342"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.06.038"},{"key":"e_1_2_7_29_1","first-page":"683","article-title":"Peristaltic hemodynamics of a new pediatric circulatory assist system for Fontan circulation using shape memory alloy fibers","volume":"2013","author":"Yamada A","year":"2013","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"e_1_2_7_30_1","first-page":"8353","article-title":"Structural design of a newly developed pediatric circulatory assist device for Fontan circulation by using shape memory alloy fiber","volume":"2011","author":"Shiraishi Y","year":"2011","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.04.037"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2012.10.045"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000135"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.pcsu.2011.01.015"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.04.051"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000040"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.02.031"}],"container-title":["Artificial Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Faor.12549","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/aor.12549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:47:25Z","timestamp":1695491245000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/aor.12549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,2]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/aor.12549"],"URL":"https:\/\/doi.org\/10.1111\/aor.12549","archive":["Portico"],"relation":{},"ISSN":["0160-564X","1525-1594"],"issn-type":[{"value":"0160-564X","type":"print"},{"value":"1525-1594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,2]]}}}